Chronic Thromboembolic Pulmonary Hypertension, Inspiratory Muscle Training, Inspiratory Muscle Weakness, Pulmonary Arterial Hypertension
Conditions
Brief summary
Inspiratory muscle training for 8 weeks in patients with pulmonary hypertension.
Detailed description
32 patients with PH will perform: 1) pulmonary function tests; 2) measurement of maximal inspiratory pressure (MIP) and endurance; 3) six-minute walk test and 5) incremental and constant load cardiopulmonary exercise test (\ 75% of maximal work-rate) and step test. Inspiratory muscle training will consist of twice daily sessions of 30 breaths (\ 50% PiMAX, 4-5 minutes per session) for 8 weeks. The SHAM group will perform sessions of 30 breaths with no inspiratory load.
Interventions
OTHERinspiratory muscle training
inspiratory muscle training with 50% of MIP
OTHERPlacebo training
placebo training with PowerBreathe (without inspiratory load)
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Federal University of São Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* CTEPH confirmed by RHC and imaging * NYHA FC II-IV
Exclusion criteria
* Limitation to cycling * Recent syncope or clinical deterioration
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| exercise capacity¨- cardiopulmonary exercise testing | week 8 | TLim (seconds) |
| exercise capacity - 6-min walk test | week 8 | distance (m) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ventilatory responses | Week 8 | VE/VCO2 |
Countries
Brazil
Outcome results
None listed