Constipation
Conditions
Brief summary
Constipation is a prevalent intestinal disorder. Lactobacillus casei strain Shirota (LcS) shows potential effect on alleviating constipation. This study evaluated the impact of fermented milk containing LcS on stool consistency and frequency. The stool short chain fatty acid and gut microbiota were also assessed.
Interventions
DIETARY_SUPPLEMENTLactobacillus casei strain Shirota
a bottle of 100 mililiter probiotic dairy beverage containing 10\^8 CFU Lactobacillus casei strain Shirota every day after lunch.
Sponsors
China Agricultural University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* meet ROME Ⅲ criteria for functional constipation * normal body mass index between 18.5 and 29.9
Exclusion criteria
* had a serious disease; * used systemic antibiotics or antimycotics medication and antidiarrheal or laxative medication in the 30 days prior to the study; * allergic to milk protein; * constipated because of organic or neurological lesions; * participated in any other studies within 2 months prior to this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of stool consistency | change from baseline stool consistency at four-week intervention |
| change of defecation frequency | change from baseline defecation frequency at four-week intervention |
| change of constipation-related symptom scores | change from baseline constipation-related symptom scores at four-week intervention |
Secondary
| Measure | Time frame |
|---|---|
| Changes in stool short chain fatty acid content | change from baseline stool short chain fatty acid content at four-week intervention |
| Changes in gut microbiota | change from baseline gut microbiota at four-week intervention |
Outcome results
None listed