Secondhand Smoking in Asthmatic Children

Association Between Maternal Smoking and GSTP1 and TNFa Polymorphism in Children With Asthma/Wheezing

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03099902

Enrollment

Registered

2017-04-04

Start date

2010-11-01

Completion date

2015-09-01

Last updated

2017-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma in Children, Wheezing

Keywords

Asthma, Wheezing, GSTP1, TNFa, Secondhand smoking, Passive smoking, Intrauterine smoking

Brief summary

This study will investigate the interaction between GSTP1 / TNFa polymorphisms and passive smoking in children with asthma/wheezing. Contemporary second hand-smoke exposure will be confirmed by laboratory testing.

Interventions

DIAGNOSTIC_TESTLung function

Spirometry test

DIAGNOSTIC_TESTWhite blood cell DNA extraction

GSTP1 and TNFa polymorphisms with PCR

DIAGNOSTIC_TESTUrinary testing

Urinary nicotine and cotinine detection

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

12 Months to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* Subjects 1-18 years old with doctor diagnosed asthma/wheezing

Exclusion criteria

* Premature birth (\< 36 gestation weeks) * Asthma-like symptoms due to other conditions (infectious, congenital, mechanical)

Design outcomes

Primary

Measure	Time frame
GSTP1 and TNFa variants in children with asthma	0 days

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026