General Anesthesia
Conditions
Brief summary
Patients were randomized into 2 groups according to the anesthetic, propofol or sevoflurane. Induction and maintenance were standardized, and after the end of surgery, two steady-state recordings were performed at BIS 25 and BIS 55. Bispectral Index and ECG were continuously recorded and cardiac autonomic nervous activity was investigated using spectral analysis of RR Interval variability
Interventions
DRUGSevoflurane
General anesthesia using sevoflurane as a hypnotic agent
DRUGPropofol
General anesthesia using propofol as a hypnotic agent
DRUGRemifentanil
General anesthesia using remifentanil as an analgesic.
Sponsors
Hôpital Armand Trousseau
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
13 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* ASA risk classification 1 or 2, * scheduled for middle ear surgery, or cardiovascular ANS activity.
Exclusion criteria
* preoperative medications that interfere with the autonomic nervous system * preoperative medications that interfere with the central nervous system
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spectral analysis of heart rate variability with a bispectral index of 25 | During surgical procedure | Fast Fourier Transform applied to heart rate signal recording |
| Spectral analysis of heart rate variability with a bispectral index of 55 | During surgical procedure | Fast Fourier Transform applied to heart rate signal recording |
Countries
France
Outcome results
None listed