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A Study to Test the Safety and Effectiveness of Nivolumab Combined With Daratumumab in Patients With Pancreatic, Non-Small Cell Lung or Triple Negative Breast Cancers, That Have Advanced or Have Spread

Phase 1/2 Study to Evaluate the Safety and Preliminary Efficacy of Nivolumab Combined With Daratumumab in Participants With Advanced or Metastatic Solid Tumors

Status
Completed
Phases
Phase 1Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03098550
Enrollment
105
Registered
2017-03-31
Start date
2017-06-15
Completion date
2020-07-06
Last updated
2021-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Advanced Cancer

Keywords

Non-small cell lung cancer (NSCLC), Triple Negative Breast Cancer (TNBC), Pancreatic Cancer (PAC)

Brief summary

The purpose of this study is to determine whether a combination of Nivolumab and Daratumumab is safe and effective when treating Pancreatic, Non-Small Cell Lung or Triple Negative Breast Cancers, that have advanced or have spread.

Interventions

BIOLOGICALNivolumab

Specified dose on specified days

BIOLOGICALDaratumumab

Specified dose on specified days

Sponsors

Janssen Biotech, Inc.
CollaboratorINDUSTRY
Bristol-Myers Squibb
Lead SponsorINDUSTRY

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com * Patients with metastatic or advanced solid tumors * Women with histologically or cytologically confirmed triple negative breast carcinoma * Participants with histologically or cytologically confirmed pancreatic adenocarcinoma * Participants with histologically or cytologically confirmed Non Small Cell Lung Cancer (NSCLC)

Exclusion criteria

* Active brain metastases or leptomeningeal metastases. * Any serious or uncontrolled medical disorder * Prior malignancy active within the previous 3 years Other protocol defined inclusion/

Design outcomes

Primary

MeasureTime frameDescription
Number of Participants With Adverse Events (AEs)From first dose to 30 days post last dose (up to 34 months)Number of participants with any grade of adverse events (AEs) graded by Common Terminology Criteria for Adverse Events (CTCAE v4.0) to determine the safety and tolerability of Nivolumab and Daratumumab
Number of Participants With Serious Adverse Events (SAEs)From first dose to 30 days post last dose (up to 34 months)Number of participants with any grade of serious adverse events (SAEs) graded by Common Terminology Criteria for Adverse Events (CTCAE v4.0) to determine the safety and tolerability of Nivolumab and Daratumumab
Number of Participants With Laboratory Abnormalities in Specific Liver TestsFrom first dose to 30 days post last dose (up to 34 months)Number of participants with laboratory abnormalities in specific liver tests based on US conventional units to determine the safety and tolerability of Nivolumab and Daratumumab. The number of participants with the following laboratory abnormalities from on-treatment evaluations will be summarized: * ALT or AST \> 3 x ULN, \> 5 x ULN, \> 10 x ULN and \> 20 x ULN * Total bilirubin \> 2 x ULN * ALP \> 1.5 x ULN * Concurrent (within 1 day) ALT or AST \> 3 x ULN and total bilirubin \> 1.5 x ULN * Concurrent (within 30 days) ALT or AST \> 3 x ULN and total bilirubin \> 1.5 x ULN * Concurrent (within 1 day) ALT or AST \> 3 x ULN and total bilirubin \> 2 x ULN * Concurrent (within 30 days) ALT or AST \> 3 x ULN and total bilirubin \> 2 x ULN
Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsFrom first dose to 30 days post last dose (up to 34 months)Number of participants with laboratory abnormalities in specific thyroid tests based on US conventional units to determine the safety and tolerability of Nivolumab and Daratumumab. The number of subjects with the following laboratory abnormalities from on-treatment evaluations will be summarized: * TSH value \> ULN and * with baseline TSH value \<= ULN * with at least one FT3/FT4 test value \< LLN within 2-week window after the abnormal TSH test * with all FT3/FT4 test values \>= LLN within 2-week window after the abnormal TSH test * with FT3/FT4 missing within 2-week window after the abnormal TSH test. * TSH \< LLN and * with baseline TSH value \>= LLN * with at least one FT3/FT4 test value \> ULN within 2-week window after the abnormal TSH test * with all FT3/FT4 test values \<= ULN within 2-week window after the abnormal TSH test * with FT3/FT4 missing within 2-week window after the abnormal TSH test
Number of Participants With Laboratory Results of Worst CTC GradeFrom first dose to 30 days post last dose (up to 34 months)Number of participants with laboratory test results of worst (CTC v4.0) grades 0-4 to determine the safety and tolerability of Nivolumab and Daratumumab

Secondary

MeasureTime frameDescription
Daratumumab Serum ConcentrationsFrom day 1 to follow-up 2 (up to 36 months)Pharmacokinetics (PK) assessed using serum concentration data for Daratumumab
Objective Response Rate (ORR)Up to 36 monthsObjective response rate (ORR) is defined as the percentage of treated participants who achieve a best response of complete response (CR) or partial response (PR) based on investigator assessments (using RECIST v1.1 criteria)
Percentage of Participants Anti Drug Antibody (ADA) by PositivityUp to 36 monthsPercentage of participants Anti Drug Antibody (ADA) to assess immunogenicity by ADA positive status and ADA negative status, relative to baseline. ADA positive is a participant with at least one ADA-positive sample relative to baseline (ADA negative at baseline or ADA titer to be at least 4-fold or greater (\>=) than baseline positive titer) at any time after initiation of treatment. ADA Negative is a participant with no ADA-positive sample after initiation of treatment
Duration of Response (DOR)Up to 36 monthsDuration of response (DOR) is defined as the time between the date of first documented response (Complete response or partial response) to the date of the first documented tumor progression as determined by Investigator (per RECIST v1.1 criteria), or death due to any cause, whichever occurs first
Best Overall Response (BOR)Up to 36 monthsBest overall response (BOR) is defined as the best response, as determined by Investigator, recorded between the date of first dose and the date of objectively documented progression per RECIST v1.1 criteria or the date of subsequent therapy, whichever occurs first.
Progression Free Survival (PFS)Up to 36 monthsProgression Free Survival (PFS) is defined as the time between the date of treatment start day and the date of first documented tumor progression, based on Investigator assessments (per RECIST v1.1 criteria), or death due to any cause, whichever occurs first.
Nivolumab Serum ConcentrationsFrom day 1 to follow-up 2 (up to 36 months)Pharmacokinetics (PK) assessed using serum concentration data for Nivolumab

Countries

Australia, Canada, France, Germany, Italy, Puerto Rico, Spain, Switzerland, United States

Participant flow

Pre-assignment details

105 participants treated

Participants by arm

ArmCount
Nivolumab + Daratumumab (TNBC)
Triple-negative breast cancer (TNBC) treated with Triple-negative breast cancer (TNBC) treated with Nivolumab IV 240 mg Q2W (weeks 3 to 24) + Daratumumab IV 16 mg/kg Q1W (weeks 1 to 8), Daratumumab IV 16 mg/kg Q2W (weeks 9-24)
41
Nivolumab + Daratumumab (NSCLC)
Non-small cell lung cancer (NSCLC) treated with Nivolumab IV 240 mg Q2W (weeks 3 to 24) + Daratumumab IV 16 mg/kg Q1W (weeks 1 to 8), Daratumumab IV 16 mg/kg Q2W (weeks 9-24)
21
Nivolumab + Daratumumab (PAC)
Pancreatic adenocarcinoma cancer (PAC) treated with Nivolumab IV 240 mg Q2W (weeks 3 to 24) + Daratumumab IV 16 mg/kg Q1W (weeks 1 to 8), Daratumumab IV 16 mg/kg Q2W (weeks 9-24)
43
Total105

Withdrawals & dropouts

PeriodReasonFG000FG001FG002
Overall StudyAdministrative reason by sponsor001
Overall StudyAdverse Event unrelated to Study Drug601
Overall StudyDeath100
Overall StudyDisease Progression301941
Overall StudyOther reasons200
Overall StudyStudy Drug Toxicity210

Baseline characteristics

CharacteristicNivolumab + Daratumumab (TNBC)Nivolumab + Daratumumab (NSCLC)Nivolumab + Daratumumab (PAC)Total
Age, Continuous55.1 Years
STANDARD_DEVIATION 13.1
59.5 Years
STANDARD_DEVIATION 8.5
61.9 Years
STANDARD_DEVIATION 9.4
58.8 Years
STANDARD_DEVIATION 11.2
Ethnicity (NIH/OMB)
Hispanic or Latino
1 Participants0 Participants0 Participants1 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
20 Participants3 Participants21 Participants44 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
20 Participants18 Participants22 Participants60 Participants
Race/Ethnicity, Customized
American Indian or Alaska Native
0 Participants0 Participants0 Participants0 Participants
Race/Ethnicity, Customized
Asian
2 Participants0 Participants0 Participants2 Participants
Race/Ethnicity, Customized
Black or African American
1 Participants0 Participants0 Participants1 Participants
Race/Ethnicity, Customized
Native Hawaiian or Other Pacific Islander
0 Participants0 Participants0 Participants0 Participants
Race/Ethnicity, Customized
Other
5 Participants0 Participants8 Participants13 Participants
Race/Ethnicity, Customized
White
33 Participants21 Participants35 Participants89 Participants
Sex: Female, Male
Female
41 Participants7 Participants20 Participants68 Participants
Sex: Female, Male
Male
0 Participants14 Participants23 Participants37 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
EG002
affected / at risk
deaths
Total, all-cause mortality
29 / 4111 / 2136 / 43
other
Total, other adverse events
40 / 4121 / 2141 / 43
serious
Total, serious adverse events
36 / 4117 / 2136 / 43

Outcome results

Primary

Number of Participants With Adverse Events (AEs)

Number of participants with any grade of adverse events (AEs) graded by Common Terminology Criteria for Adverse Events (CTCAE v4.0) to determine the safety and tolerability of Nivolumab and Daratumumab

Time frame: From first dose to 30 days post last dose (up to 34 months)

Population: All treated participants

ArmMeasureValue (COUNT_OF_PARTICIPANTS)
Nivolumab + Daratumumab (TNBC)Number of Participants With Adverse Events (AEs)41 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Adverse Events (AEs)21 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Adverse Events (AEs)42 Participants
Primary

Number of Participants With Laboratory Abnormalities in Specific Liver Tests

Number of participants with laboratory abnormalities in specific liver tests based on US conventional units to determine the safety and tolerability of Nivolumab and Daratumumab. The number of participants with the following laboratory abnormalities from on-treatment evaluations will be summarized: * ALT or AST \> 3 x ULN, \> 5 x ULN, \> 10 x ULN and \> 20 x ULN * Total bilirubin \> 2 x ULN * ALP \> 1.5 x ULN * Concurrent (within 1 day) ALT or AST \> 3 x ULN and total bilirubin \> 1.5 x ULN * Concurrent (within 30 days) ALT or AST \> 3 x ULN and total bilirubin \> 1.5 x ULN * Concurrent (within 1 day) ALT or AST \> 3 x ULN and total bilirubin \> 2 x ULN * Concurrent (within 30 days) ALT or AST \> 3 x ULN and total bilirubin \> 2 x ULN

Time frame: From first dose to 30 days post last dose (up to 34 months)

Population: All treated participants with at least one on-treatment measurement of the corresponding laboratory parameter

ArmMeasureGroupValue (COUNT_OF_PARTICIPANTS)
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 3XULN6 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 5XULN5 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 10XULN2 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 20XULN0 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsTOTAL BILIRUBIN > 2XULN1 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALP > 1.5XULN10 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 1.5XULN WITHIN ONE DAY1 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 1.5XULN WITHIN 30 DAYS1 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 2XULN WITHIN ONE DAY1 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 2XULN WITHIN 30 DAYS1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 2XULN WITHIN ONE DAY1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 3XULN2 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALP > 1.5XULN5 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsTOTAL BILIRUBIN > 2XULN1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 5XULN2 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 2XULN WITHIN 30 DAYS1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 1.5XULN WITHIN 30 DAYS1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 10XULN1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 1.5XULN WITHIN ONE DAY1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 20XULN0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 1.5XULN WITHIN 30 DAYS5 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 20XULN0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsTOTAL BILIRUBIN > 2XULN8 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALP > 1.5XULN34 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 2XULN WITHIN ONE DAY5 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 1.5XULN WITHIN ONE DAY5 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 3XULN10 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsCONCURRENT ALT OR AST ELEVATION > 3XULN WITH TOTAL BILIRUBIN > 2XULN WITHIN 30 DAYS5 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 5XULN6 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Liver TestsALT OR AST > 10XULN3 Participants
Primary

Number of Participants With Laboratory Abnormalities in Specific Thyroid Tests

Number of participants with laboratory abnormalities in specific thyroid tests based on US conventional units to determine the safety and tolerability of Nivolumab and Daratumumab. The number of subjects with the following laboratory abnormalities from on-treatment evaluations will be summarized: * TSH value \> ULN and * with baseline TSH value \<= ULN * with at least one FT3/FT4 test value \< LLN within 2-week window after the abnormal TSH test * with all FT3/FT4 test values \>= LLN within 2-week window after the abnormal TSH test * with FT3/FT4 missing within 2-week window after the abnormal TSH test. * TSH \< LLN and * with baseline TSH value \>= LLN * with at least one FT3/FT4 test value \> ULN within 2-week window after the abnormal TSH test * with all FT3/FT4 test values \<= ULN within 2-week window after the abnormal TSH test * with FT3/FT4 missing within 2-week window after the abnormal TSH test

Time frame: From first dose to 30 days post last dose (up to 34 months)

Population: All treated participants with at least one on-treatment TSH measurement

ArmMeasureGroupValue (COUNT_OF_PARTICIPANTS)
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN4 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH TSH <= ULN AT BASELINE4 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH AT LEAST ONE FT3/FT4 TEST VALUE < LLN1 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH ALL OTHER FT3/FT4 TEST VALUES >= LLN2 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH FT3/FT4 TEST MISSING1 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN1 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH TSH >= LLN AT BASELINE1 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH AT LEAST ONE FT3/FT4 TEST VALUE > ULN1 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH ALL OTHER FT3/FT4 TEST VALUES <= ULN0 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH FT3/FT4 TEST MISSING0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH ALL OTHER FT3/FT4 TEST VALUES <= ULN2 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN3 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN2 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH FT3/FT4 TEST MISSING0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH TSH <= ULN AT BASELINE3 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH FT3/FT4 TEST MISSING0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH AT LEAST ONE FT3/FT4 TEST VALUE > ULN0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH AT LEAST ONE FT3/FT4 TEST VALUE < LLN1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH TSH >= LLN AT BASELINE2 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH ALL OTHER FT3/FT4 TEST VALUES >= LLN2 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH AT LEAST ONE FT3/FT4 TEST VALUE > ULN0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH ALL OTHER FT3/FT4 TEST VALUES >= LLN0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH FT3/FT4 TEST MISSING1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN2 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH ALL OTHER FT3/FT4 TEST VALUES <= ULN1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH TSH >= LLN AT BASELINE1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN4 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH < LLN WITH FT3/FT4 TEST MISSING1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH TSH <= ULN AT BASELINE2 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Abnormalities in Specific Thyroid TestsTSH > ULN WITH AT LEAST ONE FT3/FT4 TEST VALUE < LLN3 Participants
Primary

Number of Participants With Laboratory Results of Worst CTC Grade

Number of participants with laboratory test results of worst (CTC v4.0) grades 0-4 to determine the safety and tolerability of Nivolumab and Daratumumab

Time frame: From first dose to 30 days post last dose (up to 34 months)

Population: All treated participants

ArmMeasureGroupCategoryValue (COUNT_OF_PARTICIPANTS)
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 013 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 14 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 24 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 11 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 11 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 31 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 030 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 033 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 114 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 27 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 35 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 4NA Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinNot Reported2 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 029 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 31 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 45 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountNot Reported2 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 027 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 17 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 24 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 31 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesNot Reported2 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 023 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 17 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 32 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseNot Reported5 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 016 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 115 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 22 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 34 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseNot Reported4 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 019 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 115 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 21 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 32 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseNot Reported4 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 030 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 15 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 31 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinNot Reported5 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 030 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 15 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 21 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineNot Reported5 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 029 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 10 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 24 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 32 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousNot Reported6 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 015 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 113 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 26 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminNot Reported7 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 09 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseNot Reported31 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 015 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 11 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseNot Reported25 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 035 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaNot Reported5 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 023 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 112 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaNot Reported5 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 14 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 23 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaNot Reported4 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 033 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 14 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaNot Reported4 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 033 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 12 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaNot Reported6 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 025 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 18 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 22 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaNot Reported6 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 034 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 11 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaNot Reported6 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 12 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaNot Reported6 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 010 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 19 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaNot Reported22 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 019 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 10 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 20 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 30 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 40 Participants
Nivolumab + Daratumumab (TNBC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaNot Reported22 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 021 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 11 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 21 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 31 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 14 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 014 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 015 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 21 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 15 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 17 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 21 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 20 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 015 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 20 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 10 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 25 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 31 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 015 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 14 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 22 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 018 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 21 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 10 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseNot Reported13 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 20 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 06 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 11 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 21 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaNot Reported15 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseNot Reported13 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 020 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 10 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 20 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaNot Reported1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 012 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 17 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 14 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 20 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 31 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 06 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaNot Reported1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 31 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 018 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 017 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 05 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 20 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 12 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 13 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 20 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 017 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaNot Reported15 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 05 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 19 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 27 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaNot Reported1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 4NA Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 019 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 016 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 14 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 20 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 11 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 20 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 11 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 21 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 31 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 10 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 013 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaNot Reported1 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 14 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 21 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 33 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 016 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 016 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 13 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 14 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 21 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 31 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 21 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseNot Reported0 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 012 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 01 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 16 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 30 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 20 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 32 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 40 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 113 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 030 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 25 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 14 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 23 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 07 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 36 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 30 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 31 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 035 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 119 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeBilirubinNot Reported0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 015 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 036 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 038 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 25 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 14 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 042 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 20 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 121 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 15 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 30 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 21 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 20 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 10 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesNot Reported0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeCreatinineNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 26 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 033 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 20 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 21 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 12 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 35 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 24 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 30 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 014 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 33 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 06 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 16 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 11 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePhosphorousNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 31 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 015 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaNot Reported27 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 111 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 114 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypocalcemiaNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 05 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 212 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 21 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaGrade 31 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 123 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 213 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlbuminNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 040 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 11 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 212 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 20 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 21 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 33 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 31 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 12 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperkalemiaNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 313 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAmylaseNot Reported5 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinGrade 4NA Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 30 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 031 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 20 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 30 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 15 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHemoglobinNot Reported0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseNot Reported0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 21 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 024 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 33 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 30 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 20 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseGrade 41 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 118 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 033 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLipaseNot Reported2 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseNot Reported0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 20 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypoglycemiaGrade 30 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 10 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 31 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 20 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyperglycemiaNot Reported28 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlkaline PhosphataseNot Reported0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 30 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypercalcemiaGrade 042 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypermagnesemiaNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 16 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypernatremiaNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 038 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 019 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 020 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradePlatelet CountNot Reported0 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAspartate AminotransferaseGrade 020 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 115 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 035 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaNot Reported1 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 20 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeAlanine AminotransferaseGrade 34 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 37 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypomagnesemiaGrade 14 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeLeukocytesGrade 13 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHyponatremiaGrade 40 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Laboratory Results of Worst CTC GradeHypokalemiaGrade 33 Participants
Primary

Number of Participants With Serious Adverse Events (SAEs)

Number of participants with any grade of serious adverse events (SAEs) graded by Common Terminology Criteria for Adverse Events (CTCAE v4.0) to determine the safety and tolerability of Nivolumab and Daratumumab

Time frame: From first dose to 30 days post last dose (up to 34 months)

Population: All treated participants

ArmMeasureValue (COUNT_OF_PARTICIPANTS)
Nivolumab + Daratumumab (TNBC)Number of Participants With Serious Adverse Events (SAEs)29 Participants
Nivolumab + Daratumumab (NSCLC)Number of Participants With Serious Adverse Events (SAEs)14 Participants
Nivolumab + Daratumumab (PAC)Number of Participants With Serious Adverse Events (SAEs)29 Participants
Secondary

Best Overall Response (BOR)

Best overall response (BOR) is defined as the best response, as determined by Investigator, recorded between the date of first dose and the date of objectively documented progression per RECIST v1.1 criteria or the date of subsequent therapy, whichever occurs first.

Time frame: Up to 36 months

Population: All treated participants

ArmMeasureGroupValue (COUNT_OF_PARTICIPANTS)
Nivolumab + Daratumumab (TNBC)Best Overall Response (BOR)Progressive Disease (PD)22 Participants
Nivolumab + Daratumumab (TNBC)Best Overall Response (BOR)Stable Disease (SD)8 Participants
Nivolumab + Daratumumab (TNBC)Best Overall Response (BOR)Complete Response (CR)0 Participants
Nivolumab + Daratumumab (TNBC)Best Overall Response (BOR)Unable to Determine (UTD)9 Participants
Nivolumab + Daratumumab (TNBC)Best Overall Response (BOR)Partial Response (PR)2 Participants
Nivolumab + Daratumumab (NSCLC)Best Overall Response (BOR)Partial Response (PR)2 Participants
Nivolumab + Daratumumab (NSCLC)Best Overall Response (BOR)Complete Response (CR)0 Participants
Nivolumab + Daratumumab (NSCLC)Best Overall Response (BOR)Stable Disease (SD)10 Participants
Nivolumab + Daratumumab (NSCLC)Best Overall Response (BOR)Progressive Disease (PD)9 Participants
Nivolumab + Daratumumab (NSCLC)Best Overall Response (BOR)Unable to Determine (UTD)0 Participants
Nivolumab + Daratumumab (PAC)Best Overall Response (BOR)Unable to Determine (UTD)3 Participants
Nivolumab + Daratumumab (PAC)Best Overall Response (BOR)Progressive Disease (PD)31 Participants
Nivolumab + Daratumumab (PAC)Best Overall Response (BOR)Complete Response (CR)0 Participants
Nivolumab + Daratumumab (PAC)Best Overall Response (BOR)Stable Disease (SD)9 Participants
Nivolumab + Daratumumab (PAC)Best Overall Response (BOR)Partial Response (PR)0 Participants
Secondary

Daratumumab Serum Concentrations

Pharmacokinetics (PK) assessed using serum concentration data for Daratumumab

Time frame: From day 1 to follow-up 2 (up to 36 months)

Population: All pharmacokinetic participants

ArmMeasureGroupValue (GEOMETRIC_MEAN)Dispersion
Nivolumab + Daratumumab (TNBC)Daratumumab Serum ConcentrationsCycle 7 day 1294.8322 µg/mL
Nivolumab + Daratumumab (TNBC)Daratumumab Serum ConcentrationsCycle 2 Day 1 (hour 4)735.2131 µg/mLGeometric Coefficient of Variation 36.9
Nivolumab + Daratumumab (TNBC)Daratumumab Serum ConcentrationsFollow-up 2134.0478 µg/mL
Nivolumab + Daratumumab (TNBC)Daratumumab Serum ConcentrationsCycle 4 day 1559.8988 µg/mLGeometric Coefficient of Variation 31
Nivolumab + Daratumumab (TNBC)Daratumumab Serum ConcentrationsCycle 3 day 1629.9607 µg/mLGeometric Coefficient of Variation 19.8
Nivolumab + Daratumumab (TNBC)Daratumumab Serum ConcentrationsFollow-up 1177.5615 µg/mLGeometric Coefficient of Variation 65
Nivolumab + Daratumumab (TNBC)Daratumumab Serum ConcentrationsCycle 2 Day 1 (hour 0)332.9353 µg/mLGeometric Coefficient of Variation 29.6
Nivolumab + Daratumumab (TNBC)Daratumumab Serum ConcentrationsCycle 1 Day 1 (hour 8)334.1819 µg/mLGeometric Coefficient of Variation 28.1
Nivolumab + Daratumumab (NSCLC)Daratumumab Serum ConcentrationsCycle 3 day 1477.6488 µg/mLGeometric Coefficient of Variation 25
Nivolumab + Daratumumab (NSCLC)Daratumumab Serum ConcentrationsFollow-up 257.3349 µg/mL
Nivolumab + Daratumumab (NSCLC)Daratumumab Serum ConcentrationsCycle 1 Day 1 (hour 8)310.7272 µg/mLGeometric Coefficient of Variation 15.6
Nivolumab + Daratumumab (NSCLC)Daratumumab Serum ConcentrationsCycle 2 Day 1 (hour 0)321.6084 µg/mLGeometric Coefficient of Variation 25.7
Nivolumab + Daratumumab (NSCLC)Daratumumab Serum ConcentrationsCycle 2 Day 1 (hour 4)641.8146 µg/mLGeometric Coefficient of Variation 26.3
Nivolumab + Daratumumab (NSCLC)Daratumumab Serum ConcentrationsCycle 4 day 1393.5442 µg/mLGeometric Coefficient of Variation 48.9
Nivolumab + Daratumumab (NSCLC)Daratumumab Serum ConcentrationsCycle 7 day 1515.2495 µg/mLGeometric Coefficient of Variation 21.9
Nivolumab + Daratumumab (NSCLC)Daratumumab Serum ConcentrationsFollow-up 1157.5960 µg/mLGeometric Coefficient of Variation 62.2
Nivolumab + Daratumumab (PAC)Daratumumab Serum ConcentrationsCycle 4 day 1406.9487 µg/mLGeometric Coefficient of Variation 28.2
Nivolumab + Daratumumab (PAC)Daratumumab Serum ConcentrationsCycle 2 Day 1 (hour 0)275.1521 µg/mLGeometric Coefficient of Variation 35.9
Nivolumab + Daratumumab (PAC)Daratumumab Serum ConcentrationsFollow-up 1184.1510 µg/mLGeometric Coefficient of Variation 51.7
Nivolumab + Daratumumab (PAC)Daratumumab Serum ConcentrationsCycle 7 day 1229.0854 µg/mL
Nivolumab + Daratumumab (PAC)Daratumumab Serum ConcentrationsCycle 1 Day 1 (hour 8)277.6708 µg/mLGeometric Coefficient of Variation 28.4
Nivolumab + Daratumumab (PAC)Daratumumab Serum ConcentrationsCycle 3 day 1473.0335 µg/mLGeometric Coefficient of Variation 23.8
Nivolumab + Daratumumab (PAC)Daratumumab Serum ConcentrationsCycle 2 Day 1 (hour 4)569.8158 µg/mLGeometric Coefficient of Variation 27.4
Nivolumab + Daratumumab (PAC)Daratumumab Serum ConcentrationsFollow-up 28.4517 µg/mLGeometric Coefficient of Variation 158.4
Secondary

Duration of Response (DOR)

Duration of response (DOR) is defined as the time between the date of first documented response (Complete response or partial response) to the date of the first documented tumor progression as determined by Investigator (per RECIST v1.1 criteria), or death due to any cause, whichever occurs first

Time frame: Up to 36 months

Population: All treated participants with objective response

ArmMeasureValue (MEDIAN)
Nivolumab + Daratumumab (TNBC)Duration of Response (DOR)4.17 Months
Nivolumab + Daratumumab (NSCLC)Duration of Response (DOR)9.40 Months
Secondary

Nivolumab Serum Concentrations

Pharmacokinetics (PK) assessed using serum concentration data for Nivolumab

Time frame: From day 1 to follow-up 2 (up to 36 months)

Population: All pharmacokinetic participants

ArmMeasureGroupValue (GEOMETRIC_MEAN)Dispersion
Nivolumab + Daratumumab (TNBC)Nivolumab Serum ConcentrationsCycle 7 Day 144.8 µg/mLGeometric Coefficient of Variation 32.8
Nivolumab + Daratumumab (TNBC)Nivolumab Serum ConcentrationsCycle 3 Day 152.9 µg/mLGeometric Coefficient of Variation 34.8
Nivolumab + Daratumumab (TNBC)Nivolumab Serum ConcentrationsCycle 4 Day 187.0 µg/mLGeometric Coefficient of Variation 34
Nivolumab + Daratumumab (TNBC)Nivolumab Serum ConcentrationsFollow-up 223.5 µg/mLGeometric Coefficient of Variation 60.6
Nivolumab + Daratumumab (TNBC)Nivolumab Serum ConcentrationsFollow-up 148.9 µg/mLGeometric Coefficient of Variation 44
Nivolumab + Daratumumab (NSCLC)Nivolumab Serum ConcentrationsCycle 11 Day 1124.3 µg/mLGeometric Coefficient of Variation 46.5
Nivolumab + Daratumumab (NSCLC)Nivolumab Serum ConcentrationsCycle 4 Day 177.9 µg/mLGeometric Coefficient of Variation 37.6
Nivolumab + Daratumumab (NSCLC)Nivolumab Serum ConcentrationsFollow-up 217.4 µg/mLGeometric Coefficient of Variation 96.1
Nivolumab + Daratumumab (NSCLC)Nivolumab Serum ConcentrationsFollow-up 171.6 µg/mLGeometric Coefficient of Variation 58.9
Nivolumab + Daratumumab (NSCLC)Nivolumab Serum ConcentrationsCycle 7 Day 1116.2 µg/mLGeometric Coefficient of Variation 23.8
Nivolumab + Daratumumab (NSCLC)Nivolumab Serum ConcentrationsCycle 3 Day 143.5 µg/mLGeometric Coefficient of Variation 26.6
Nivolumab + Daratumumab (PAC)Nivolumab Serum ConcentrationsFollow-up 26.3 µg/mLGeometric Coefficient of Variation 89.7
Nivolumab + Daratumumab (PAC)Nivolumab Serum ConcentrationsCycle 3 Day 142.5 µg/mLGeometric Coefficient of Variation 29.7
Nivolumab + Daratumumab (PAC)Nivolumab Serum ConcentrationsCycle 7 Day 183.3 µg/mL
Nivolumab + Daratumumab (PAC)Nivolumab Serum ConcentrationsFollow-up 132.8 µg/mLGeometric Coefficient of Variation 48.6
Nivolumab + Daratumumab (PAC)Nivolumab Serum ConcentrationsCycle 4 Day 164.3 µg/mLGeometric Coefficient of Variation 31.4
Secondary

Objective Response Rate (ORR)

Objective response rate (ORR) is defined as the percentage of treated participants who achieve a best response of complete response (CR) or partial response (PR) based on investigator assessments (using RECIST v1.1 criteria)

Time frame: Up to 36 months

Population: All treated participants

ArmMeasureValue (NUMBER)
Nivolumab + Daratumumab (TNBC)Objective Response Rate (ORR)4.9 Percentage of Participants
Nivolumab + Daratumumab (NSCLC)Objective Response Rate (ORR)9.5 Percentage of Participants
Nivolumab + Daratumumab (PAC)Objective Response Rate (ORR)0 Percentage of Participants
Secondary

Percentage of Participants Anti Drug Antibody (ADA) by Positivity

Percentage of participants Anti Drug Antibody (ADA) to assess immunogenicity by ADA positive status and ADA negative status, relative to baseline. ADA positive is a participant with at least one ADA-positive sample relative to baseline (ADA negative at baseline or ADA titer to be at least 4-fold or greater (\>=) than baseline positive titer) at any time after initiation of treatment. ADA Negative is a participant with no ADA-positive sample after initiation of treatment

Time frame: Up to 36 months

Population: All immunogenicity participants

ArmMeasureGroupValue (NUMBER)
Nivolumab + Daratumumab (TNBC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityNivolumab Baseline ADA Positive0.00 Percentage of Participants
Nivolumab + Daratumumab (TNBC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityDaratumumab Baseline ADA Positive0.00 Percentage of Participants
Nivolumab + Daratumumab (TNBC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityNivolumab ADA Positive0.00 Percentage of Participants
Nivolumab + Daratumumab (TNBC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityNivolumab ADA Negative100.0 Percentage of Participants
Nivolumab + Daratumumab (TNBC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityDaratumumab ADA Positive0.00 Percentage of Participants
Nivolumab + Daratumumab (TNBC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityDaratumumab ADA Negative100.0 Percentage of Participants
Nivolumab + Daratumumab (NSCLC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityDaratumumab ADA Negative100.0 Percentage of Participants
Nivolumab + Daratumumab (NSCLC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityNivolumab Baseline ADA Positive6.3 Percentage of Participants
Nivolumab + Daratumumab (NSCLC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityNivolumab ADA Negative100.0 Percentage of Participants
Nivolumab + Daratumumab (NSCLC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityDaratumumab ADA Positive0.00 Percentage of Participants
Nivolumab + Daratumumab (NSCLC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityDaratumumab Baseline ADA Positive5.6 Percentage of Participants
Nivolumab + Daratumumab (NSCLC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityNivolumab ADA Positive0.00 Percentage of Participants
Nivolumab + Daratumumab (PAC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityDaratumumab Baseline ADA Positive0.00 Percentage of Participants
Nivolumab + Daratumumab (PAC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityNivolumab ADA Positive0.00 Percentage of Participants
Nivolumab + Daratumumab (PAC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityDaratumumab ADA Negative100.0 Percentage of Participants
Nivolumab + Daratumumab (PAC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityNivolumab ADA Negative100.0 Percentage of Participants
Nivolumab + Daratumumab (PAC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityNivolumab Baseline ADA Positive0.00 Percentage of Participants
Nivolumab + Daratumumab (PAC)Percentage of Participants Anti Drug Antibody (ADA) by PositivityDaratumumab ADA Positive0.00 Percentage of Participants
Secondary

Progression Free Survival (PFS)

Progression Free Survival (PFS) is defined as the time between the date of treatment start day and the date of first documented tumor progression, based on Investigator assessments (per RECIST v1.1 criteria), or death due to any cause, whichever occurs first.

Time frame: Up to 36 months

Population: All treated participants

ArmMeasureValue (MEDIAN)
Nivolumab + Daratumumab (TNBC)Progression Free Survival (PFS)1.22 Months
Nivolumab + Daratumumab (NSCLC)Progression Free Survival (PFS)4.85 Months
Nivolumab + Daratumumab (PAC)Progression Free Survival (PFS)1.22 Months

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026