Mechanical Ventilation, Neutrophil Lymphocyte Ratio, Serum Createnine
Conditions
Keywords
cardiac preconditioning, open heart surgery, createnine, inflammation
Brief summary
An association between white blood cell count (WBC), neutrophil-lymphocyte ratio , and inflammatory process is well known . Ischemic preconditioning reduces the inflammation
Detailed description
Preliminary evidence has suggested the role of inflammation in development and prognosis of cardiovascular diseases and cancers. Most of the prognostic studies failed to account for the effects of co-morbid conditions as these might have raised the systemic inflammation. We used neutrophil lymphocyte ratio (NLR) as a measure of systemic inflammation and investigated its association with cardiac preconditioning in open heart surgery .
Interventions
PROCEDUREischemic preconditioning
ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles
DRUGPharmacologic preconditionig
Pharmacologic preconditionig will be attained by sevoflurane anesthesia
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
intervention group well be pretreated with cardiac preconditioning
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* 18-60 years old * American Society of Anesthesiologists physical status II and III * Patients scheduled for open heart surgery * no active inflammatory process
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of Neutrophil lymphocyte ratio | during first two postoperative days |
Countries
Egypt
Outcome results
None listed