Allergy; Dander
Conditions
Keywords
Dog allergy, Can f 5, Male dog, Female dog, Allergen components
Brief summary
A new male-specific dog-allergen-component has been found (Can f 5) which indicates possible differences in allergic reactions to male and female dogs. This has not yet been tested in real life. The aim is to test if sensitization only to the male-dog specific allergen-component, Can f 5, results in a positive skin prick test (SPT) to male dog extract and not female dog extract. In addition, the investigators want to investigate if allergic symptoms only occur when exposed to the male dog extract by conjunctival provocation.
Interventions
DIAGNOSTIC_TESTMale dog
Male dog extract
DIAGNOSTIC_TESTFemale dog
Female dog extract
Sponsors
Copenhagen Studies on Asthma in Childhood
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Participants in the COPSAC 2000 cohort * Positive component test (\>0.3 ISU) to Can f 1, Can f 2, Can f 3 or Can f 5
Exclusion criteria
* Uncontrolled asthma * Eye-surgery within the past 6 months * Antihistamine allergy * and others
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Male vs. female dog SPT in Can f 5 mono sensitized patients | 6 months | In the patients that have a positive SPT (\> 2mm) to dog and are monosensitized to the Can f 5 component, the investigatiors want to compare the reaction to SPT (pos/neg) to male vs. female dog extract in the same patient using logistic regression analysis with mixed effects to account for repeated measures. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Male vs. female dog conjunctival provocation in Can f 5 mono sensitized patients | 6 months | In the patients that have a positive SPT (\> 2mm) to dog and are monosensitized to the Can f 5 component, the investigatiors want to compare the reaction to conjunctival provocation (positive/negative) to male vs. female dog extract in the same patient using logistic regression analysis with mixed effects to account for repeated measures. |
| Male vs. female dog conjunctival provocation in dog poly sensitized patients | 6 months | In the patients that have a positive SPT (\> 2mm) to dog and are sensitized to the Can f 1, 2 and/or 3 component, the investigatiors want to compare the reaction to conjunctival provocation (pos/neg) to male vs. female dog extract in the same patient using logistic regression analysis with mixed effects to account for repeated measures. |
| Male vs. female dog SPT in dog poly sensitized patients | 6 months | In the patients that have a positive SPT (\> 2mm) to dog and are sensitized to the Can f 1, 2 and/or 3 component, the investigatiors want to compare the reaction to SPT (pos/neg) to male vs. female dog extract in the same patient using logistic regression analysis with mixed effects to account for repeated measures. |
| Can f 5 vs. conjunctival provocation | 6 months | To investigate the correlation between sIgE level to the Can f 5 component and the threshold of reaction to the male dog extract at the conjunctival provocation, using a general linear model. |
| SPT vs. conjunctival provocation | 6 months | To investigate the correlation between SPT wheal size to the male dog extract and the threshold of reaction to the male dog extract at the conjunctival provocation, using a general linear model. |
| Can f 5 vs. SPT size | 6 months | To investigate the correlation between specific Immunoglobulin E (sIgE) level to the Can f 5 component and the SPT wheal size to the male dog extract using a general linear model. |
Countries
Denmark
Outcome results
None listed