Titanium-Prepared Platelet Rich Fibrin in the Sinus Lifting Procedure

Comparison of the Clinic, Radiographic and Histological Effects of Allograft and T-PRF (Titanium-Prepared Platelet Rich Fibrin) Materials in the Sinus Lifting Procedure. Preliminary Results From a Pilot Randomised Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03096210

Enrollment

Registered

2017-03-30

Start date

2013-03-11

Completion date

2015-03-02

Last updated

2020-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Maxillary Sinus

Keywords

Maxillar sinus, Titanium-Prepared Platelet Rich Fibrin, Allograft, implant

Brief summary

This study evaluates the radiographic, histological and clinical comparisons of the completely autologous T-PRF or allograft effectiveness at the maxillary sinus elevation procedure.

Detailed description

Participants randomly divided into 2 groups and the test group had a Schneiderian membrane elevation with using balloon lifting technique and after that sinus was filled with T-PRF produced from the patients' blood and 4 months waiting period has been entered. At the end of the 4th month, the bone samples were received from the implant slots and sent to histological evaluation. After 3 months, implant stability was measured and recorded. In the control group, the same procedures were followed and sinus was filled with only allograft. Waiting period was changed to 6 months for this group.

Interventions

OTHERTitanium-Prepared Platelet Rich Fibrin

Blood samples were collected from the each participant's arm in the test group by 20 ml syringe and then was transferred into 10ml grade IV titanium tube without anticoagulant. After centrifugation of blood samples (2800 rpm, 12 minutes) at room temperature, the T-PRF clot was removed from the tubes with sterile tweezers. 6 blood tubes were collected for a sinus floor elevation/lifting operation and 6 T-PRFs were prepared for each participant.

OTHERAllograft (CTBA Allograft)

After careful elevation of the schneiderian membrane without perforation, allograft was only used for augmentation of the sinus floor in the control group.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

42 Years to 69 Years

Healthy volunteers

Yes

Inclusion criteria

* Participants having been diagnosed to display a residual crest height of less than 5mm in posterior maxilla and non-smokers were included.

Exclusion criteria

* Participants with blood platelet disorders, infectious and metabolic diseases, ongoing chemotherapy or radiotherapy, history of chronic sinusitis associated with maxillary sinuses, taking any antibiotics and/or anti-inflammatory drugs were excluded.

Design outcomes

Primary

Measure	Time frame	Description
Histological Examination	At the first 4 and 6th months post surgery for the test and control groups, respectively.	Percentage (%) of new and old trabeculae formation post surgery

Secondary

Measure	Time frame	Description
Radiological Examination	Within the first 4 and 6 months	Density (hu) measurements
Implant stability measurements	Within the 3 months after implant surgery	Implant Stability Quotient values (50-80 ISQ)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026