Volumetric Bone Mineral Density and it's Relationship With Osteoporotic Fractures in Parkinson's Disease

Determinants of Volumetric Bone Mineral Density at the Tibia and Radius and it's Relationship With Osteoporotic Fractures in Idiopathic Parkinson's Disease

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03095690

Acronym

DOPPA

Enrollment

Registered

2017-03-30

Start date

2016-01-07

Completion date

2017-06-21

Last updated

2018-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic Parkinson's Disease

Keywords

Osteoporosis, Parkinson, HR-pQCT, bone microstructure, fracture risk

Brief summary

Idiopathic Parkinson's disease (IPD) is the second most frequent neurodegenerative disease. Its association with osteroporosis and fragility fracture is now clearly demonstrated, but the determinants of this osteoporosis are yet to be explained. Our aim was to study factors associated with volumetric bone mineral density (vBMD) and bone microstructure at the tibia and radius in IPD.

Interventions

OTHERHigh resolution peripheral scanner (HRpQCT).

radius and tibia osteodensitometry measurement

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

35 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Patients with idiopathic Parkinson's disease according to the criteria of the UKPDBB. * Parkinson's disease of moderate severity (Index HOEHN and Yahr \<5) * Patient can respond to questionnaires, with or without help

Exclusion criteria

* Patients with active psychiatric illness preventing the realization of examinations * Severe Parkinson's disease (Index HOEHN and Yahr ≥5 ) * Heavy-morbidity including heart failure NYHA\> 3 or chronic respiratory failure, terminal or severe renal impairment known dialyzed * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Measurement of volumetric bone mineral density at the tibia and radius	0 hour	Measurement performed by High Resolution peripheral Quantitative Computed Tomography (HRpQCT)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026