Evaluation of Root Coverage by Connective Graft and Different Root Conditioning Methods

Evaluation of Root Coverage by Subepithelial Connective Graft Associated to Root Conditioning by Citric Acid Plus Tetracycline and Antimicrobial Photodynamic Therapy: A Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03095378

Enrollment

Registered

2017-03-29

Start date

2014-03-10

Completion date

2017-03-10

Last updated

2017-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Recession

Keywords

gingival recession

Brief summary

The aim of this study was to evaluate the effect of two root-conditioning agents used in conjunction with subepithelial connective graft technique on root coverage outcomes. One is citric acid plus tetracycline and the other is antimicrobial photodynamic therapy.

Detailed description

Citric acid plus tetracycline has properties of root surface decontamination, surface demineralization and exposure of collagen fibers. Antimicrobial photodynamic therapy has been widely used in Periodontics to obtain reduction of periodontopathogenic bacteria with absence of systemic side effects and minimal bacterial resistance. Also, it has properties of root demineralization and exposure of collagen fibers. These properties may enhance root coverage in procedures of subepithelial connective graft.

Interventions

PROCEDUREControl

Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with scaling and root planing

PROCEDUREcitric acid plus tetracycline

Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with citric acid plus tetracycline

PROCEDUREantimicrobial photodynamic therapy

Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with antimicrobial photodynamic therapy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Masking description

The outcome assessor did not have access to patient's records

Intervention model description

Interventions in different patients

Eligibility

Sex/Gender

ALL

Age

20 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Gingival recession - Miller's class I or II (2 to 5 mm of height) at least in one tooth * Indication of root coverage by dentin hypersensitivity or esthetic

Exclusion criteria

* Smokers * Pregnancy * Systemic medication use that could impair wound healing or surgery procedure * Systemic diseases as diabetes, uncontrolled hypertension, coagulation diseases, kidney diseases.

Design outcomes

Primary

Measure	Time frame	Description
Total root coverage measured with a periodontal probe in mm	one year	Distance from cemento-enamel junction to gingival margin = 0 mm

Secondary

Measure	Time frame	Description
Keratinized mucosa width measured with a periodontal probe in mm	one year	Ideal if keratinized mucosa width \> 5mm
Dentin hypersensitivity measured by applying an air jet on teeth and patient fills up a visual analogue scale	one year	Ideal if scale = 0

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026