Cysticercosis
Conditions
Keywords
Burkina Faso, Community-based randomized controlled trial, Cysticercosis, Implementation Research, Effectiveness
Brief summary
This is a pre-post randomized community-based controlled trial aimed at estimating the effectiveness of an educational package developed using PRECEDE PROCEED to reduce the cumulative incidence of Taenia solium cysticercosis in three Provinces of Burkina Faso. The study design included an 18-months baseline study to measure baseline cumulative incidence of cysticercosis followed by an 18-month post randomization study to measure the effectiveness of the intervention. Sixty villages of three Provinces of Burkina Faso were included. The primary outcome was the change in the baseline to post randomization cumulative incidence in the intervention group compared to the control group.
Interventions
OTHEREducational package
The educational package was offered to 30 villages post randomization. The field team completed the SARAR PHAST with community members for 2-3 days in each intervention village. The movie was projected every night for 2-3 days in each intervention village.
Sponsors
AFRICSanté
Institute of Tropical Medicine, Belgium
Institut de Recherche en Sciences de la Sante, Burkina Faso
University of Ouagadougou, Burkina Faso
University Hospital, Limoges
Centre Universitaire Souro Sanou
Technical University of Munich
Brown University
University of Oklahoma
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
This is a pre-post community-based randomized controlled trial. The unit of randomization is the village (community)
Eligibility
Sex/Gender
ALL
Age
5 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
The unit of randomization and analysis of this study is the village. Therefore, the eligibility criteria were determined at the village level. Inclusion Criteria: * Population of at least 1000 at the 2006 census * Present on the map of the Institut Géographique du Burkina 2000 * Separated from another village by at least 5 kilometers.
Exclusion criteria
* Village located on a National or Provincial road * Village located within 20 km of Koudougou or Ouagadougou * Regional or Provincial Capital * Absence of pigs in the village At the individual level, the following eligibility criteria were used: Inclusion Criteria: * Aged 5 years old or more * Has lived in the village for at least 12 months * Not planning to move in the next three years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Human active cysticercosis cumulative incidence | baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization | Sero conversion to the AgELISA test to detect antigens of cysticercosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Porcine active cysticercosis prevalence | baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization | Sero-positivity to the AgELISA test to detect antigens of cysticercosis |
| Change in knowledge, attitude and practices | baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization | Change in answers to the questionnaire through time |
| Cumulative incidence of epilepsy and progressively worsening severe chronic headaches | baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization | development of neurological disorders among those followed up at least twice |
| Stigmatization of epilepsy | 18 months follow-up post randomization | Attitudes and knowledge regarding epilepsy post randomization |
Countries
Burkina Faso
Outcome results
None listed