Patient Specific Computational Modeling
Conditions
Keywords
Kinematics, MRI Scans, CT Scan, Single-Photon Emission, finger interphalangeal joint
Brief summary
The proximal interphalangeal (PIP) joint is the second joint in the finger from the finger tip. The outcome following replacement surgery of this joint is considered unsatisfactory. In order to improve these outcomes, it would be helpful to understand the geometry of the joint, how it moves and the forces that are involved. This can be achieved using computer models that model the bones and the soft tissues - musculoskeletal models. In order to make these models as representative as possible, they should be generated using anatomical data. Data will initially be extracted from patients' existing magnetic resonance imaging (MRI) and computed tomography (CT) scans. This will enable the computer model to begin being constructed. In parallel to the model initialisation, anatomical and motion data of the PIP joint of healthy volunteers will be collected. The necessary data will be collected using CT and MRI scans, as well as optical motion tracking methods. These data will then be used to populate the musculoskeletal model. Once the model is constructed, it will be used to simulate the motion of the joint and look at the effect of a simulated PIP joint replacement. This information should then provide insight as to how PIP joint replacements might be improved in future.
Interventions
OTHERMotion capture
Capture kinematics of finger movements
DIAGNOSTIC_TESTMR scan
Capture MR images of hand and fingers in three postures
DIAGNOSTIC_TESTCT scan
Capture CT images of hand and fingers in three postures
Sponsors
University of Southampton
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* In general good health * University of Southampton members of staff * Over 18 years old and able to provide informed consent * No known problems relating to the PIP joint
Exclusion criteria
* Volunteers involved in other studies concerned with the function and anatomy of the PIP joint which would have adverse effects on this study and/or the study in which they are currently involved. * Those undergoing treatment related to the PIP joint * No metallic object should be present in the scanner and therefore those with any implanted metallic devices, or other devices which may cause or be caused adverse effects (e.g. metal plate, pacemaker)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Capturing hand kinematics using Vicon optical motion capture | 3 years | Capture hand kinematics of 10 healthy volunteers |
| Capturing images of the soft tissue in the hand using MR imaging | 3 years | Capture MR images of the hand for same 10 healthy volunteers as Outcome 1 |
| Capturing images of the bony structures in the hand using CT scanning | 3 years | Capture CT images of the hand for same 10 healthy volunteers as Outcome 1 |
Countries
United Kingdom
Outcome results
None listed