Abdominal Sepsis
Conditions
Brief summary
This study aims to evaluate the efficacy of ultrasound derived variables in prediction of success of weaning from mechanical ventilation in critically ill patients with abdominal sepsis
Detailed description
Difficult weaning from mechanical ventilation (MV) is a common problem in critically ill patients. Many parameters have been developed to aid weaning from MV such as P/F ratio (PO2/FiO2) and rapid shallow breathing index (respiratory rate/tidal volume); however, sensitivity and specificity for most variables are still variable in literature. Diaphragmatic dysfunction is a common cause of weaning failure (2) however most of the traditional methods used for evaluation of diaphragmatic function (fluoroscopy, trans-diaphragmatic pressure measurement) are invasive and not available. Ultrasound assessment of diaphragmatic function has been developed recently providing an easy and safe method for evaluation of diaphragmatic excursion and thickening. In this study we will evaluate the ability of the diaphragmatic function to predict weaning success in patients with abdominal sepsis. After weaning, patients will be divided into two groups; group of successful weaning (group S) and group with failed weaning (group F) both groups will be compared as regards all clinical, laboratory, and ultrasonographic parameters recorded before weaning, further analysis will be done for patients with repeated trials of weaning (more than one trial or more than one week MV) and those with simple weaning (first time for weaning). A 7-10 Mega Hertz linear ultrasound probe (Mindray machine) set to B mode, the diaphragm will be visualized by placing the transducer perpendicular to the chest wall, in the eighth or ninth intercostal space, between the anterior axillary and the midaxillary lines, to observe the zone of apposition of the muscle 0.5 to 2 cm below the costophrenic sinus. The diaphragm thickness will be measured from the middle of the pleural line to the middle of the peritoneal line. Then, the diaphragmatic fraction thickening (DTF) will be calculated as percentage Diaphragmatic movement will be measured in all patients with a 3.5 Mega Hertz US probe placed over one of the lower intercostal spaces in the right anterior axillary line for the right diaphragm and the left midaxillary line for the left diaphragm.
Interventions
None listed
Sponsors
Cairo University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Critically ill patients with abdominal sepsis with history of MV for more than 48 hours
Exclusion criteria
* Age \< 18 years and surgical dressings over the right lower rib cage which would preclude ultrasound examination will be excluded. Also, patients with chest trauma, thoracotomy, diaphragmatic paralysis, diaphragmatic dysfunction, diaphragmatic injury, diaphragmatic surgery and patients with neuromuscular diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diaphragmatic thickening fraction | five minutes before spontaneous breathing trial | (calculated as maximum thickness - minimum thickness / maximum thickness) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rapid shallow breathing index (RSBI) | five minutes before spontaneous breathing trial | Respiratory rate/tidal volume in litres |
| Arterial blood gases | five minutes before spontaneous breathing trial and five minutes before patient extubation | Partial oxygen pressure and Partial carbon dioxide pressure |
| Diaphragmatic excursion | five minutes before spontaneous breathing trial and five minutes before patient extubation | (measured in millimeters) |
| Heart rate | five minutes before spontaneous breathing trial and five minutes before patient extubation | the patient heart rate measured as beat.minute |
| Arterial blood pressure | five minutes before spontaneous breathing trial and five minutes before patient extubation | systolic and diastolic blood pressure measured in mmHg |
| Number of weaning trials | during the last 7 days | number of weaning trials before this trial |
Countries
Egypt
Outcome results
None listed