Xerosis, Xerosis Cutis, Dry Skin; Eczema
Conditions
Brief summary
The purpose of the study is to compare the changes in the appearance of dry skin after the use various moisturizers: white petrolatum ointment, coconut oil, jojoba oil, and almond oil in patients with dry skin.
Detailed description
The goal of this study is to compare how the appearance of dry skin changes before and after the use of following moisturizers: white petrolatum, coconut oil, jojoba oil and almond oil). Up to 40 subjects from Banner-University Medical Center/University of Arizona dermatology clinics and University of California, Davis dermatology clinics (up to 20 subjects per site) who have dry skin will be enrolled in this study and randomized to receive the four moisturizers on four locations on their forearms.There will be a total of 3 study sessions: baseline, and approximately 1 and 2 weeks for follow up assessment. At each visit, dry skin severity will be evaluated by a trained observer using a validated Dry Skin Score, skin barrier biophysical properties (transepidermal water loss and hydration) will be measured, and digital photos of the test sites will be taken for image analysis.
Interventions
OTHERvirgin coconut oil
One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive virgin coconut oil application twice daily for 2 weeks.
OTHERvirgin jojoba oil
One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive virgin jojoba oil application twice daily for 2 weeks.
OTHERvirgin almond oil
One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive virgin almond oil application twice daily for 2 weeks.
OTHERwhite petrolatum ointment
One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive white petrolatum ointment application twice daily for 2 weeks.
Sponsors
University of California, Davis
University of Arizona
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Male and female, at least 18 years of age 2. Subject must receive a diagnosis of dry skin by a dermatologist. 3. Subject must be able to comprehend and read the English language.
Exclusion criteria
1. Subjects who do not fit the inclusion criteria. 2. Subjects unable to or unwilling to comply with the study procedures 3. Prior known allergy to white petrolatum, coconut oil, almond oil, or jojoba oil. 4. People who have used products containing white petrolatum, jojoba oil, coconut oil, or almond oil within the past week. 5. People with a known diagnosis of ichthyosis. 6. A subject who, in the opinion of the investigator, will be un-cooperative or unable to comply with study procedures. 7. Subject unable to speak or read the English language, since all consents and instructions will be provided in English. 8. Those that are prisoners or cognitively impaired
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The appearance of xerosis | 14 days | The clinical severity of xerosis of the 4 location will be graded by a trained observed using a previously validated Dry Skin Scale and by analysis of the digital photos. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Skin barrier biophysical properties of xerosis | 14 days | Transepidermal water loss (TEWL) and stratum corneum hydration status will be measured using hand-held, noninvasive, skin barrier measuring devices (Tewameter and moistureMeter) |
Countries
United States
Outcome results
None listed