Functional Capacity and Quality of Life Following Septal Myectomy in Patients With HCM

Conditions

Hypertrophic Cardiomyopathy

Brief summary

Investigators aim to assess changes in exercise capacity and quality of life after septal myectomy in patient with hypertrophic cardiomyopathy.

Detailed description

The objective of this study is to examine change in quality of life and functional capacity as respectively measured by, Quality of Life Questionnaires and six-minute walk test distance, following septal myectomy in patients with obstructive hypertrophic cardiomyopathy, as compared to prior to surgery.

Milind Y. Desai, Natalie Szpakowski, Albree Tower‐Rader, Barb Bittel, Agostina M. Fava et al. (11 authors)

Journal of the American Heart Association2024-12-256 citations

10.1161/jaha.124.037058

Patient reported outcomes in obstructive hypertrophic cardiomyopathy undergoing myectomy: Results from SPIRIT-HCM study.

Tower-Rader A, Szpakowski N, Popovic ZB, Bittel B, Fava A, Ospina S, Xu B, Thamilarasan M, Mentias A, Smedira NG, Desai MY.

2023-06-0913 citations

10.1016/j.pcad.2023.06.001

Abstract 11324: Association of Patient Reported Outcomes With NYHA Class and Functional Capacity in Symptomatic Obstructive Hypertrophic Cardiomyopathy: An Analysis of Spirit-HCM Study

Albree Tower Rader, Natalie Szpakowski, Zoran Popović, Barbara Bittel, Agostina M. Fava et al. (10 authors)

Circulation2022-11-08

10.1161/circ.146.suppl_1.11324

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

No

Inclusion criteria

* Scheduled to undergo septal myectomy. * Established diagnosis of obstructive HCM defined as: LVH Thickness ≥15mm left ventricular outflow tract gradient ≥50mmHg

Exclusion criteria

* Prior septal myectomy or alcohol septal ablation * Prior myocardial infarction * Uncontrolled arrhythmias including ventricular tachycardia and atrial fibrillation * Uncontrolled hypertension * Angiographically documented coronary stenosis \>50%, if available at time of screening * Inability to provide informed consent * Inability to walk without assistive devices * Peripheral artery disease with claudication

Design outcomes

Primary

Measure	Time frame	Description
Change in Quality of Life Change in Summary Score	1 year post myectomy	Mild improvement in Quality of Life summary score (increase in 5 points) as measured by Kansas City Cardiomyopathy Questionnaire -KCCQ

Secondary

Measure	Time frame	Description
Change in Quality of Life Change in Patient Reported Outcomes	1 year post myectomy	Quality of Life as measured by The Patient-Reported Outcomes Measurement Information System (PROMIS) Questionnaire
Change in Quality of Life Change in Duke's Activity Status Index (DASI)	1 year post myectomy	Quality of Life as measured by the Duke's Activity Status Index (DASI) Questionnaire
Change in functional capacity post myectomy	1 year post myectomy	Functional capacity will be measured by 6 minute walk

Countries

United States

Outcome results