Normal Pressure Hydrocephalus
Conditions
Keywords
Shunting, Brain constructure, Neural network
Brief summary
With the advent of the aging society, dementia becomes the focus of common people. As for the neurodegeneration dementia, no disease modifying treatments have been discovered. Idiopathic normal pressure hydrocephalus (iNPH) is considered as one of reversible dementia, which can be hint by the surgery. In addition, dementia of iNPH is the typical subcortical dementia. Therefore exploring the pathogenic mechanism is conducive to the early diagnosis and treatment. This research is to monitor the changing of iNPHGS, cognitive function, walking ability as well as brain construction imaging and neural network before and after ventriculo-peritoneal shunting in order to demonstrate the pathogenesis of triads. In the process, the supplementary test, for instance, CSF tap test, will be validated the predictive value.
Interventions
PROCEDUREventriculo-peritoneal shunting
A mainstream therapy for NPH. It involves the device of CSF flow control of shunts and accessories(CFDA(I)20143665605)
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
ncluded will be subjects with a probable diagnosis of NPH. The diagnosis will be based primarily on presence of gait impairment plus at least one other impairment in urinary symptoms, cognition impairment or both. 1. Are 50 years old or older 2. Patients who understand the study protocol 3. Patients who meet the criteria for NPH 1. A typical personal history 2. A typical brain imaging on head CT or MRI 3. Normal LP findings excluding other conditions 4. Exclusion of other conditions causing the symptomatology
Exclusion criteria
1. Patients below the age of 50 years. 2. Patients who underwent shunt surgery before
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The brain constructure and neural network changing one year after shunting | one year after shunting | Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume •Neural network( DMN)by the resting functional MRI |
| The brain constructure and neural network changing one day after shunting | Day 1 after shunting | * Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume * Neural network( DMN)by the resting functional MRI |
| The brain constructure and neural network changing 90 days after shunting | Day 90 after shunting | Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume •Neural network( DMN)by the resting functional MRI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of the clinical syndrome of normal pressure hydrocephalus | Day 1 after shunting | iNPHGS |
Other
| Measure | Time frame | Description |
|---|---|---|
| Cognition assessments | Day 1 after shunting | The neuropsychological battery assessment (including MMSE, MOCA as well as cognitive domains especially executive function examinations) |
| Walking ability evaluation | Day 1 after shunting | Including 10m walking test, up and go tests |
Countries
China
Contacts
Primary ContactCaiyan Liu, MD
Backup ContactLiling Dong, MD
Outcome results
None listed