Aerobic Interval Training in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Hypoxemia

Effects of Aerobic Interval Training on Cardiac Function, With Special Focus on Pulmonary Pressures and Right Sided Function, in Patients With Chronic Obstructive Pulmonary Disease and Hypoxemia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03092622

Enrollment

Registered

2017-03-28

Start date

2017-04-01

Completion date

2019-12-31

Last updated

2020-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension, Pulmonary, Hypoxia, Pulmonary Disease, Chronic Obstructive

Keywords

Exercise Therapy

Brief summary

Patients with severe Chronic Obstructive Pulmonary Disease (COPD) and low oxygen levels in the blood are at risk of developing pulmonary hypertension and strain on the right side of the heart, both of which are known to increase symptoms and worsen prognosis It is not fully established whether interval exercise training in patients with severe COPD and concomitant low oxygen levels is beneficial. This study aims to evaluate the effects of aerobic interval exercise training in patients with severe COPD and low oxygen levels in the blood, with a particular emphasis on such effects on the cardiovascular system and pulmonary circulation.

Interventions

OTHERExercise

Exercise training intervention as described earlier.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

45 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Chronic Obstructive Pulmonary Disease (COPD) * Forced Expiratory Volume 1 second (FEV1) \<60% of predicted * FEV1%FVC \<70 % of predicted (FVC = Forced Vital Capacity) * Qualify for Long term oxygen therapy (LTOT), or presence of significant desaturation on exercise.

Exclusion criteria

* Unstable ischaemic heart disease or valvular heart disease. * Active malignant disease. * Substance abuse. * Physical or mental disability that prevents participation in the exercise programme or testing. * Pregnancy. * Exacerbation of COPD or respiratory tract infection last 6 weeks before. * Completed pulmonary rehabilitation programme or other organised exercise programme last 3 month * Use of high doses of systemic steroids.

Design outcomes

Primary

Measure	Time frame	Description
Pulmonary artery pressure	Change from baseline at 10 weeks	Examined by right heart catheterisation

Other

Measure	Time frame	Description
Cardiac function	Change from baseline at 10 weeks	assessed by echocardiography
Respiratory function	Change from baseline at 10 weeks	assessed by spirometry
Functional capacity	Change from baseline at 10 weeks	assessed by shuttle walk test
Symptoms	Change from baseline at 10 weeks	COPD Assessment Test (CAT)
Quality of life	Change from baseline at 10 weeks	St George Respiratory Questionnaire (SGRQ)

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026