Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study

Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03092401

Acronym

HPS

Enrollment

142

Registered

2017-03-27

Start date

2015-10-01

Completion date

2017-03-31

Last updated

2017-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatopulmonary Syndrome, Liver Cirrhosis

Keywords

Liver transplantation, Hepatopulmonary Syndrome, Liver Cirrhosis

Brief summary

Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 \< 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations. Its prevalence varies between 4 and 32%. Numerous treatments have been tried but the only efficient therapy to cure the syndrome is liver transplantation. Without transplantation it is associated with a higher mortality which is the reason why hepatopulmonary syndrome patients have a higher priority to transplantation. However it appears in some restricted studies that hepatopulmonary syndrome is associated with more postoperative complications (infections, vascular and biliary complications, prolonged length of mechanical ventilation…). The investigators hypothesised that hepatopulmonary syndrome patients have more postoperative complications after liver transplantation than non hepatopulmonary syndrome patients matched on age, MELD (Model for End-Stage Liver Disease) score, comorbidities, perioperative transfusion and noradrenaline doses.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Liver transplanted patients

Exclusion criteria

* Living donor transplantation * Bipartition transplantation * Non-heat-beating donor transplantation * Minor * Double or multiple organ transplantation * Non cirrhotic patients * Retransplantation

Design outcomes

Primary

Measure	Time frame	Description
Postoperative complication rates in hepatic transplant patients with or without hepatopulmonary syndrome	1 year post liver transplantation	Collection of medical (cardiac, pulmonary, renal, infectious, neurological) and Surgical (vascular, digestive) complications in hepatic transplant patients with or without hepatopulmonary syndrome

Secondary

Measure	Time frame
Length of Mechanical Ventilation	1 year post liver transplantation
Length of ICU stay	1 year post liver transplantation
Length of Hospital Stay	1 year post liver transplantation
Delay of hepatopulmonary syndrome resolution	1 year post liver transplantation

Outcome results