Physical Activity
Conditions
Brief summary
Physical training may improve physical capacity and health parameters in various systemic autoimmune diseases. Therefore, the present study will assess the role of an exercise training program in patients with relapsing polychondritis.
Detailed description
Impact of physical training in patients with relapsing polychondritis.
Interventions
OTHERPhysical training
Sponsors
University of Sao Paulo
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Patients will submitted to physical training (12-weeks, twice/week)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Fullfill the classification criteria of McADAM et al. (1976) * Using prednisone ≤ 0.5 mg/kg/day in the last three months * Sedentary
Exclusion criteria
* Disease relapsing * Overlapping disease * Chronic and/or current infections (viral, bacterial or fungal) * Patients undergoing major surgery within six months before the study * With commitment to ambulation (joint affection in limbs) * Smoking * Diabetes mellitus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiopulmonary test | 12 weeks | Patients will undertake a maximal graded exercise test on a treadmill, with increments in velocity and grade at every minute until volitional exhaustion. VO2peak will be considered as the average of the final 30 s of the test. Ventilatory threshold (VAT) will be determined when ventilatory equivalent for VO2 (VE/VO2) increased without a concomitant increase in ventilatory equivalent for carbon dioxide (VE/VCO2). Respiratory compensation point (RCP) will be determined when VE/VO2 and VE/VCO2 increased simultaneously. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Strength muscle tests | 12 weeks | The dynamic 1-RM for the leg-press and the bench-press exercises, arm curl (with the dominant arm), and isometric strength (assessed by handgrip, with the dominant arm) will be assessed at baseline and after the intervention. |
| Healthy Assessment Questionnaire (HAQ) | 12 weeks | Especific questionnaire to assess the quality of life. Pontuaction: 0.00-3.00 |
| Functional muscle tests | 12 weeks | Muscle function will be evaluated through the TUG and the TST tests |
| Muscle biopsy | 12 weeks | After local anesthesia, a cutaneous incision will be made in lateral thigh face. The biopsy will be done using the Bergstrom needle. Histological (hematoxylin and eosin)/immunohistochemical (CD4, CD8, CD68, CD20, C5b-9, MHCI, MHCII, CD31) analysis will be performed in muscle samples (at baseline and after 12 weeks) in all patients (present study) |
Countries
Brazil
Outcome results
None listed