High Flow Nasal Cannula
Conditions
Brief summary
High-humidity nasal cannula (HFNC) has been shown to be effective in improving oxygenation and avoiding intubation in multiple randomized control trials, it is also suitable and feasible for long term use. Aerosol delivery via HFNC will minimize interruptions and improve patient compliance, bench study and radionuclide imaging study done in healthy volunteers demonstrated that aerosol can be effectively delivered using HFNC. This study aims to evaluate the efficacy of bronchodilator delivered via HFNC in chronic pulmonary obstructive disease or asthma patients.
Detailed description
Chronic obstructive pulmonary disease or asthma patients who have positive response in bronchodilator test will be consented and enrolled, patients come back for the second bronchodilator assessment within one to three days after the initial bronchodilator test. Albuterol with different concentration will be provided to the patients via HFNC, patients will be assessed by spirometry after each concentration until bronchodilator response is positive and does not improve after the next dose.
Interventions
DEVICEHigh flow nasal cannula
High flow nasal cannula is a soft and flexible nasal prongs with adjustable head strap fits over the patient's ears, it delivers a broad variety of gas flows directly into the nares without gas jetting.
Albuterol is a short acting inhaled bronchodilator
Sponsors
People's Hospital of Xinjiang Uygur Autonomous Region
Rush University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Diagnose with COPD or asthma * Bronchodilator test is positive (According to ATS guidelines, FEV1 change from initial more than 12% and FEV1 absolute change more than 200 mL); * Age \> 18yrs and \< 90yrs
Exclusion criteria
* Recent pulmonary exacerbation * Mental disease * Uncooperative * Reluctant to participate * Patients who are unable to come back to get the second spirometry within three days * Contraindicated to Albuterol (Ventolin, GSK) * Rest HR \> 100 beats/min * Serum K+ \< 2.8 mmol/L
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FEV1 change from initial | 30-60 mins | FEV1 abs Δ: post FEV 1 - pre FEV1 and FEV1 %Δinit: (post FEV1 - pre FEV1)/pre FEV1 × 100 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Breath sound | 30-60 mins | Wheezing |
| Heart rate | 30-60 mins | The number of heart beats per minute |
| Respiratory rate | 30-60 mins | About 4,630,000 results (0.68 seconds) Search Results The number of breaths per minute |
| Side effects | 30-60 mins | Tremor |
Countries
China
Outcome results
None listed