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Effect of Perioperative Dexmedetomidine Administration on Outcome in Cardiac Surgery Patients

The Effect of Prophylactic Dexmedetomidine Administration on the Outcome in Patients Undergoing Surgery With Cardiopulmonary Bypass

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03091166
Enrollment
169
Registered
2017-03-27
Start date
2016-12-31
Completion date
2019-04-30
Last updated
2019-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patient Outcome Assessment

Brief summary

Investigation of effect of perioperative Dexmedetomedine administration on mortality, length of ICU and hospital stay, delirium onset, major adverse cardiac and cerebrovascular events, acute kidney injury in cardiac surgery patients.

Interventions

DRUGDexmedetomidine

Sponsors

Moscow Regional Research and Clinical Institute (MONIKI)
Lead SponsorOTHER_GOV

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Written informed agreement * Elective surgery * Use of CPB

Exclusion criteria

* Previous prolonged immobilization * Reoperation

Design outcomes

Primary

MeasureTime frameDescription
30DM30 days after surgery30-day mortality
Delirium30 days after surgeryPostoperative delirium

Secondary

MeasureTime frameDescription
Subsyndromal delirium30 days after surgerySubsyndromal postoperative delirium
AKI7 days after surgeryAcute kidney injury
VIS5 days after surgeryVasoactive- Inotropic Score
H-LOS30 days after surgeryHospital length of stay
ICU-LOS7 days after surgeryLength of ICU stay
MACCE30 days after surgeryMajor adverse cardiac and cerebrovascular events

Countries

Russia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026