Aggressive Periodontitis, Generalized
Conditions
Keywords
mechanical treatment, implant
Brief summary
The investigators planed to observe the microbiome of an aggressive periodontitis patient, during mechanical treatment, surgery(if indicated) and implant placement. The investigators designed to observe the changes after mechanical treatment.Then, the investigators will compare the sub-mucosa microbiome of implant and the subgingival community. The investigators expected a different community after treatment, and there could be similarity between implant and nature teeth.
Interventions
PROCEDUREmechanical treatment(mainly scaling and root planing), periodontal surgery(if indicated), implant placement.
The investigators shall follow the regular procedure to these patients.
Sponsors
Peking University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
1. Subjects were between 18-35 years old and diagnosed with generalized aggressive periodontitis (GAgP) according to the 1999 International Classification of Periodontal Diseases (Armitage 1999); 2. At least 20 teeth in the first appointment and at least 3 teeth(other than first molars and central incisors)with a probing depth(PD) ≥ 6mm, clinical attachment level (CAL)≥5mm; 3. The clinical diagnosis was confirmed by evidence of inter-proximal bone loss on full-mouth periapical radiographs; 4. Family history of aggressive periodontitis.
Exclusion criteria
1. Uncontrolled systemic conditions including diabetes and hypertension; 2. Pregnant or lactating; 3. Smoking; 4. Received periodontal treatment within the previous 6 months or antibiotic medication during the previous 3 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes of diversity of subgingival community (compare the sub-mucosa microbiome of implant and the subgingival community) | Baseline, 6 weeks after mechanical treatment | the diversity of subgingival community before and after mechanical treatment |
| changes of prevalence and abundance of OTUs | Baseline, 6 weeks after mechanical treatment | compute and compare the prevalence and abundance of OTUs |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes of bleeding index | Baseline, 6 weeks after mechanical treatment, before implantation, 1 months after second stage surgery, every month after prosthetic treatment until 2 years. | bleeding index after probing |
| changes of probing depth | Baseline, 6 weeks after mechanical treatment, before implantation, 1 months after second stage surgery, every month after prosthetic treatment until 2 years. | probing depth of indicated sites |
| clinical attachment loss | Baseline, 6 weeks after mechanical treatment, before implantation, 1 months after second stage surgery, every month after prosthetic treatment until 2 years. | by probe, the distance between CEJ and gingival sulcus |
Countries
China
Outcome results
None listed