Upper Respiratory Tract Infections, Asthma, Exhaled Breath
Conditions
Brief summary
Respiratory virus infections cause a majority of asthma exacerbations in the fall to spring months. Current diagnostic platforms for respiratory viruses have limitations including cost, availability, and invasiveness. The use of noninvasive breath collection to analyze breath metabolites may be used to differentiate virus-infected asthmatics from other causes of acute asthma exacerbations.
Interventions
DIAGNOSTIC_TESTExhaled breath condensate collection
Breath from humans is cooled, condensed, and collected
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
University of California, Davis
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Asthma, Age ≥12, Symptoms/signs of an early asthma exacerbation, Ability to provide exhaled breath condensate (EBC) x15 min, Body mass index (BMI) ≥18
Exclusion criteria
* Chronic lung diseases other than asthma (e.g., chronic obstructive pulmonary disease \[COPD\], lung cancer, fibrotic lung disease, etc.), Smoking in the past 7 days, Eating or non-clear liquids \<4 hrs prior to EBC collection, Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Breath metabolite differences between groups | 36 months | Metabolites from breath will be identified and quantified using gas chromatography-mass spectrometry; these will be compared between groups. Specific breath metabolites include isoprostane, linear and branched alkanes (C6-C9), alcohols, and thiol-containing moieties. However, we will also measure metabolites in an un-targeted manner. |
Countries
United States
Outcome results
None listed