Anesthesia
Conditions
Brief summary
Perioperative fluid management is crucial for patients' outcome. Muller et al developed a Mini-fluid challenge method to predict fluid responsiveness and the efficacy. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.
Detailed description
Perioperative fluid management is crucial for patients' outcome. Series of studies have indicated that adequate fluid management optimizes the cardiac out put, improves tissue perfusion, thus decrease the risk of postoperative morbidity. Muller et al developed a Mini-fluid challenge method to predict fluid responsiveness and the efficacy. To the best of our knowledge, the efficacy of the test was not discussed in the perioperative care in prone position surgery. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.
Interventions
OTHERMini-fluid challenge
Mini-fluid challenge test with 100mL colloid infusion in 1 min
Sponsors
National Taiwan University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
meet both of 1. Patients receiving scheduled prone position spine surgery 2. BMI 18.5\ 30 kg.m-2
Exclusion criteria
1. age younger then 20 yrs or elder than 80 yrs 2. pregnant women 3. patients in intensive care units 4. patients with the underlying disease including respiratory failure(FEV1/FVC \< 70 % and FEV1 \< 50%), heart failure(NYHA score =III、IV), kidney failure(eGFR\< 60 ml.min-1.1.73m-2), liver failure 5. patients with ongoing infection 6. patients allergic to voluven
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of cardiac index after fluid loading | 3hr | interpretate the correlation of mini-fluid challenge and conventional fluid challenge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pulse pressure variation(PPV) | 3hr | interpretate the correlation of PPV and conventional fluid challenge |
Other
| Measure | Time frame | Description |
|---|---|---|
| stroke volume variation(SVV) | 3hr | interpretate the correlation of SVV and conventional fluid challenge |
| plethysmographic variation index(PVI) | 3hr | interpretate the correlation of PVI and conventional fluid challenge |
Countries
Taiwan
Outcome results
None listed