MicroRNAs in Acute Kidney Injury

MicroRNAs in Acute Kidney Injury (MIRAKI) - a Pilotstudy -

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03089242

Acronym

MIRAKI

Enrollment

150

Registered

2017-03-24

Start date

2017-09-01

Completion date

2018-12-31

Last updated

2020-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Injury in Cardiac Surgery - Expression of microRNAs

Brief summary

Profiling of microRNAs and long noncoding RNAs (lncRNAs) in patients undergoing cardiac surgery. Analysis: Prediction of acute kidney injury by plasma expression profile of microRNAs?

Detailed description

In this pilot study we will include 150 patients undergoing cardiac surgery in a German university hospital. We will profile microRNA expression in plasma and urine before and at several timepoints after surgery. We will use a preselected panel of microRNAs and lncRNAs for analysis. Goal is to identify microRNAs/lncRNAs that are able to predict the occurence of AKI in these patients.

Interventions

OTHERobservation of microRNA expression

no intervention

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Inclusion criteria

* cardiac surgery

Exclusion criteria

* preexisting chronic kidney injury * inclusion in another study * pregnancy * Kidney transplantation in history * GFR \< 30 ml/min (glomerular filtration rate) * ECLS therapy (extracorporal life support)

Design outcomes

Primary

Measure	Time frame	Description
acute kidney injury	1 year	AKI Stadium II or III following cardiac surgery.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026