Embryo Transfer, Infertility, Female, Oocyte Donation
Conditions
Brief summary
It has been previously shown that although the activation of the embryonic genome can begin as early as two days of initiation of the embryonic development (D2), it is expressed on day 3 (D3). Without this activation, the embryo can not continue its development. Therefore, it has been suggested that extended culture to blastocyst stage could be an option to identify and better select embryos that have been able to carry out this activation. The purpose of this study is to compare cumulative pregnancy and live birth rates following transfer of cleavage embryos or blastocysts.
Interventions
PROCEDUREBlastocyst-stage embryo transfer strategy
Intra-uterine transfer of blastocist if in cleavage embryo stage the oocyte recipient has a mínimum of 3 availables embryos with at least one of good quality to transfer and also the inta-uterine transfer of cleavage embryo (day 3) when the recipient doesn't have the previous criteria.
PROCEDURECleavage-stage embryo transfer strategy
Inta-uterine transferring of cleavage embryo transfer (day 3 of develpment) in oocyte recipients
Sponsors
Fundacion Dexeus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Patients under their first or second cycle of a synchronous (fresh) oocyte donation cycle.
Exclusion criteria
* Preimplantation genetic screening or diagnosis cycles. * Patients with strict blastocyst-stage embryo transfer indication by the couple's treating physician.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cumulative live birth rate | at 12 months after a embryo transfer (time considered enough in order to do a minimum of one frozen-thawed cycle if pregnancy is not achieved with the fresh cycle | Total number of births considering fresh and frozen thawed embryos transferred |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cumulative pregnancy rate | at 12 months after a embryo transfer (time considered enough in order to do a minimum of one frozen-thawed cycle if pregnancy is not achieved with the fresh cycle | Total number of pregnancies confirmed by ultrasound 6 weeks after embryo transfer including fresh and thawed embryos. |
Countries
Spain
Outcome results
None listed