Alveolar Bone Loss
Conditions
Keywords
25-OH vitamin D, RANKL, Osteoprotogerin, TNF-α
Brief summary
Vitamin D has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation. Our aim was to investigate the relation between serum 25-hydroxy vitamin D levels, clinical periodontal parameters and blood serum biomarkers. The subjects were evaluated in 2 groups as chronic periodontitis (n= 30) and periodontally healthy subjects (n= 30). Periodontal parameters and fasting venous blood samples were taken from the subjects to assess each patient's periodontal status and for biochemical analyses (25-hydroxy vitamin D (25-OH vit D), osteoprotegerin (OPG), receptor activator of nuclear kappa B ligand (RANKL), C-telopeptide (CTx), tumor necrosis factor-α (TNF-α)).
Interventions
DIAGNOSTIC_TESTfasting venous blood samples
Sponsors
Ordu University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
25 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Inclusion Criteria: * never-smokers * no history of systemic disease * no patients had been under periodontal therapy and medicine for at least 6 months before the study * no pregnancy or lactation * no alcohol or antioxidant vitamin consumption. *
Exclusion criteria
* \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Biochemical parameters | Baseline | serum TNF-α |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Periodontal parameters | Baseline | The plaque index (PI) |
Outcome results
None listed