Maternal Periodontal Status and Cytokines in Preeclampsia

Maternal Periodontal Status and Gingival Crevicular Fluid Levels of Interleukin-6, Interleukin-35, and Interleukin-37 in Preeclampsia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03088228

Enrollment

Registered

2017-03-23

Start date

2015-02-02

Completion date

2016-12-31

Last updated

2017-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Diseases, Preeclampsia

Brief summary

Background: The purpose of this study is to examine the relationship between maternal preeclampsia and periodontal parameters and the correlation of these two disorders with maternal gingival crevicular fluid levels (GCF) of interleukin (IL)-35, interleukin-37 and interleukin-6. The investigators also investigated their relation to the severity of preeclampsia. Methods: 82 preeclamptic women were recruited to the study (29 healthy pregnant women, 30 mild preeclamptic patient, 23 severe preeclamptic patient ). The clinical periodontal parameters and GCF samples were collected in the first day of puerperium.

Interventions

DIAGNOSTIC_TESTgingival crevicular fluid collection

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Inclusion criteria

* Aged between 18 and 45 years * 25 and 40 weeks of gestation. * Healthy pregnants, mild and severe preeclampsia

Exclusion criteria

* Patients with accompanying diseases * multiple gestations * congenital abnormalities were excluded from the study.

Design outcomes

Primary

Measure	Time frame	Description
maternal periodontal clinical parameters and IL-37 and IL-35 and IL-6 levels	6 months	IL-37 IL-35 and IL-6 levels in maternal gingival crevicular fluid levels between the three groups

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026