DWI-MRI
Conditions
Brief summary
The study is designed to evaluate the value of DWI-MRI (Diffusion weighted magnetic resonance imaging) in predicting the efficacy of liver metastases after chemotherapy in colorectal cancer.
Interventions
The enrolled colorectal liver metastases patients will receive DWI-MRI screening to evaluate the liver metastases before the chemotherapy, after the first cycle of chemotherapy and in the regular efficacy evaluation time, respectively.
Sponsors
Fudan University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DEVICE_FEASIBILITY
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* aged ≥18 years with histologically or cytologically confirmed advanced colorectal adenocarcinoma * Eastern Cooperative Oncology Group performance status of 0 to 2 * life expectancy of ≥ 3 months * at least one measurable liver metastatic lesion in MRI (≥10mm) * have adequate bone marrow, hepatic, and renal function * previously received no palliative chemotherapy
Exclusion criteria
* patients with previous chronic inflammatory bowel disease, chronic diarrhea or recurrent bowel obstruction * patients with symptomatic brain metastases * active clinical severe infection * have contraindication of MRI screening
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Response rate | 2 months | the response rate predicted by DWI-MRI |
Secondary
| Measure | Time frame |
|---|---|
| Progression free survival | 2 months |
| Overall survival | 2 months |
Countries
China
Contacts
Primary ContactWeijian Guo
Outcome results
None listed