Unruptured Cerebral Aneurysm
Conditions
Brief summary
In neurosurgical anesthesia, propofol based total intravenous anesthesia (TIVA) is frequently used due to brain relaxation and less effect on electrophysiologic monitoring. Response to propofol can vary between individuals and be associated with clinical factors including age and weight, and genetic polymorphism. Because the importance of rapid recovery in neurosurgery with long operation time is emphasized recently, the choice and dose adjustment of anesthetics should be determined according to clinical and genetic factors. Recently, researches about genetic variations have been performed with single nucleotide polymorphism (SNP). The aim of this study is to find SNPs associated with propofol recovery and response through genome-wide association study (GWAS) in Korean adult population undergoing propofol based TIVA for clipping of unruptured cerebral aneurysm.
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Korean adult population undergoing propofol based TIVA for clipping of unruptured cerebral aneurysm
Exclusion criteria
* Patients not able to read, or understand the consent form * Ethnicity, other than Korean population * Patients refusal * Patients not to perform total intravenous anesthesia * Patients currently taking psychiatric medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time of eye opening after stopping propofol infusion | Within one hour | When operation is finished, investigator will stop the intravenous infusion of propofol. Investigators will measure the time from when propofol infusion is stopped until eye opening and extubation, respectively. The measurement will be established within about one hour from end of surgery. |
Countries
South Korea
Contacts
Primary ContactSeung Ho Choi, MD
Outcome results
None listed