Immersion Virtual Reality Training ,Stroke, Upper Extremity, Randomized Controlled Trial
Conditions
Brief summary
The investigators will conduct a single-blind, randomized controlled trial of 60 patients with subacute stroke. Patients will be randomly assigned into a control group and an intervention group. The intervention group will participate in immersion VR training for 3 weeks. The control group will receive for traditional rehabilitation training for 3 weeks. Then, the patients will be reevaluated to determine changes in upper extremity function, cognitive function, cortical and subcortical activation patterns, and performance of activities of daily living after the baseline assessment.
Interventions
OTHERimmersion virtual reality (VR)-based rehabilitation
Intervention group received VR-based rehabilitation,including Virtual kitchen and so on.The patients took part in the exercise program for 30 minutes each day, five times per week, for 3 weeks. All subjects received physiotherapy, which accounts for an average of 30 minutes of physiotherapy per day on tolerance.
The traditional rehabilitation training included occupational therapy and physical therapy, patients took part in the traditional rehabilitation training for 60 minutes each day, five times per week, for 3 weeks.
Sponsors
Second Affiliated Hospital of Wenzhou Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. having had an ischemic stroke in the first time 2. age 30 to 80 years old 3. first stroke within 2 month 4. GCS score \>8 5. the upper-limb function BrunnstromⅡ、Ⅲ
Exclusion criteria
1. hemorrhage or transient ischemic attack(TIA) 2. important organs such as heart, lung, liver, kidney function decline or failure 3. previous history of brain neurosurgery or epilepsy 4. had severe cognitive impairments or aphasia, which made the participants unable to understand the instructions given by the investigators 5. with claustrophobia and body with metal (such as metal teeth, etc.) are not suitable for to MRI scanning
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline Arm Movement Ability at 3 months | Baseline and at 3 months | The Fugl-Meyer Assessment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline Activities of Daily Living (ADL) at 3 months | Baseline and at 3 months | The Barthel index |
| Change from Baseline Cognitive Function at 3 months | Baseline and at 3 months | the Korea-MiniMental Status Evaluation (K-MMSE) |
| Change from Baseline Cortical and Subcortical Activation Patterns at 3 months | Baseline and at 3 months | Functional MRI (fMRI) |
Countries
China
Outcome results
None listed