Cirrhosis, Hepatitis
Conditions
Keywords
liver, fibrosis, MRI
Brief summary
As cirrhosis progresses, alteration of hemodynamics develops and decreased portal flow is often observed. Since direct measurement of portal pressure (HVPG) is invasive, non-invasive methods have drawn a lot of attention. MRI is one of the non-invasive methods and it is able to provide multiparametric data in one examination. Herein, we evaluate hepatic fibrosis with different stage using multiparametric MRI with emphasis on portal flow measurement.
Interventions
DIAGNOSTIC_TESTLiver MRI
Multiparametric Liver MRI including following sequences: DCE, DWI, MRE, precontrast flow measurement, fat quantification.
Sponsors
GE Healthcare
Seoul National University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* chronic liver disease (viral hepatitis, alcoholic hepatitis, or other...) * Or transplant recipient for viral hepatitis and on anti-viral agent medication * AND scheduled for liver resection, biopsy or transient elastography * AND signed informed consent
Exclusion criteria
* younger than 18 years * any contra-indication for contrast-enhanced MRI * pregnant or nursing women * biliary obstruction * unable or unwilling to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| hepatic fibrosis stage | 1 month after MRI | F0-1 vs. F2-4 using multiparametric MRI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| presence of varix | 1 month after MRI | presence of esophageal or gastric varices using multiparametric MRI |
| comparison of portal flow measurement | 1 month after MRI | comparison of portal flow measurement using DCE and precontrast flow measurement |
Countries
South Korea
Outcome results
None listed