POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03084393

Enrollment

215

Registered

2017-03-20

Start date

2017-03-01

Completion date

2018-04-30

Last updated

2020-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Cognitive Dysfunction

Keywords

non-cardiac surgery, Postoperative Cognitive Dysfunction

Brief summary

To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12. To explore whether the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin B12 could be used as predictor(s) of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* Non-cardiac surgery patients; * Age is greater than or equal to 60 years old; * Han Nationality, mother tongue is chinese; * The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; * The Geriatric Depression Scale (GDS) grade 1 or 2; * The important function without serious heart, brain, liver, kidney, lung and other organs; * The ASA class I or II; * The people signed informed consent.

Exclusion criteria

* The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; * Had severe head and face disease, trauma history or history of surgery; * The serious body disease and tobacco, wine and other substance abuse history; * The presence of malignant tumor with shorter survival disease.

Design outcomes

Primary

Measure	Time frame	Description
the neuropsychological tests	1 day before surgery(baseline)	the neuropsychological tests to measure cognitive function, including the Trail Making Test, the Grooved Pegboard Test, the Digit Span Test, the Number-Symbol Replacement Test,the Finger Tapping Test, the Word Fluency Test and the Building Block Test.
Mini-Mental score examination [MMSE]	1 day before surgery(baseline)	Mini-Mental score examination \[MMSE\] used for screening of dementia

Countries

China

Outcome results