General Anxiety Disorder, Major Depressive Disorder
Conditions
Keywords
emotional impairments, cognitive impairments
Brief summary
This study aims to 1) examine common and specific emotional and cognitive dysfunctions between Major Depression and generalized anxiety disorder; 2) Examine emotional and cognitive dysfunctions between the two disorders and healthy controls; 3) Examine the biomarkers predicting successful therapy or not.
Interventions
DEVICEfMRI
Sponsors
Sichuan Provincial People's Hospital
The Fourth People's Hospital of Chengdu
University of Electronic Science and Technology of China
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* GAD: 1. Diagnosis of Generalized Anxiety Disorder (GAD) according to DSM V criteria in a structured clinical interview for DSM-V Axis I disorders (SCID I; APA, 2014) and a confirmatory clinical interview 2. Duration of the current episode \> 3 weeks * MDD: 1. Diagnosis of current major depressive disorder in a structured clinical interview for DSM-V Axis I disorders (SCID I; APA, 2014) and a confirmatory clinical interview 2. Duration of the current episode \> 4 weeks
Exclusion criteria
* GAD: diagnosis of any other psychiatric Axis I disorder (except GAD) as a principal diagnosis within the past six months * MDD: diagnosis of any other psychiatric Axis I disorder (except MDD) as a principal diagnosis within the past six months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain activity in the emotional and cognitive core regions of the brain as assessed by fMRI | 1 hour (assessed at study inclusion) | fMRI based indices during emotional face processing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Behavioral performance during the fMRI: empathy reactivity | 1 hour (assessed at study inclusion) | Empathy in response to empathy inducing pictures (rated on Likert scale) |
| Behavioral performance during the fMRI: working memory | 1 hour (assessed at study inclusion) | Working memory performance during fMRI |
| Behavioral performance during the fMRI: face processing | 1 hour (assessed at study inclusion) | Accuracy during face processing |
| Symptom improvement after 3 months: depression | 3 months | Symptoms of depression will be assessed using validated clinical scales (e.g. BDI) |
| Symptom improvement after 3 months: anxiety | 3 months | Symptoms of generalized anxiety will be assessed using validated clinical scales (e.g. Penn State Worry Questionnaire) |
| Cognitive performance at study inclusion | 1 hour (assessed at study inclusion) | Executive functions as assessed via computerized tests (CANTAB) |
Countries
China
Contacts
Primary ContactBenjamin Becker, Dr.
Outcome results
None listed