Tooth Eruption, Atherosclerosis
Conditions
Brief summary
To determine if there is an association between Porphyromonas gingivalis infection of dental gingiva during primary tooth eruption and thickening of the radial artery intimamedial layers. Thickening of these layers in infants could be a promoting factor for later development of atherosclerosis.
Detailed description
Specific Aim 1. To determine the presence of Pg in the mouth of edentulous pre-eruption and then teething infants. Over a 9-month period 15 normal babies will be recruited for a prospective pilot study from Creighton University students. Cotton swabs of the tongue mucosa and dental plaque will be made to detect the presence of Pg by DNA analysis. Specific Aim 2. To determine the daily temperature of infants. Daily child temperatures will be recorded by the parent. Specific Aim 3. To measure the thickness of the radial artery using a 50 MHz ultrasound probe. A 50 MHz ultrasound scan will be made by a trained dental hygienist of the left radial artery at an initial visit and at 3-monthly intervals to measure IMT.
Interventions
DIAGNOSTIC_TESTUltrasound
Measurement of thickness of radial artery wall thickness by ultrasound
Sponsors
Creighton University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Months to 24 Months
Healthy volunteers
Yes
Inclusion criteria
* Pre-primary tooth eruption infants in the range of 4-8 months -
Exclusion criteria
* No erupted teeth. No diabetes, obesity, chronic inflammatory disorders, hyperlipidemia, -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial wall thickness | 9 months | Increase in thickness of intimamedia layers |
Countries
United States
Outcome results
None listed