Healthy Controls, Mild Cognitive Impairment
Conditions
Brief summary
This study plans to assess the effectiveness of performance-based functional assessments (PBFAs) and cognitive assessments in diagnosing Alzheimer's disease in Hispanic/Latino populations. The information from this study will be analyzed with data from the Rocky Mountain Alzheimer's Disease Center Bio-AD study (NCT02612376).
Interventions
None listed
Sponsors
Alzheimer's Association
University of Colorado, Denver
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
55 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Persons with age-related MCI or AD according to clinical diagnosis, consistent with National Institute on Aging-Alzheimer's Association (NIA-AA) diagnostic criteria * Community-dwelling controls * Age \> 55 years * Have been enrolled and completed at least one visit in the Bio-AD study and consent to access their data (the Rocky Mountain Alzheimer's Disease Center Bio-AD study (clinicaltrials.gov identifier: NCT02612376)) * Have capacity to provide consent; capacity will be assessed at the time of consent * Ability to complete baseline assessments * Has informant (study partner) available to complete functional interviews/survey measures
Exclusion criteria
* Presence of concomitant medical, neurological, or psychiatric illness or condition that in the opinion of the investigators would confound interpretation of study results. These include: * Korsakoff encephalopathy; * active substance abuse; * hepatitis C; * opportunistic brain infection; * brain tumor; * active neoplastic disease (skin tumors other than melanoma are not exclusionary; participants with stable prostate cancer may be included at the discretion of the project director); * multiple sclerosis; * history of clinically significant stroke; * current evidence or history in the past 2 years of * focal brain lesion, * head injury with loss of consciousness in the past year, or * DSM-5 criteria for any major psychiatric disorder, including 1. psychosis, 2. uncontrolled major depression, 3. bipolar disorder, 4. alcohol or substance abuse; 5. blindness, 6. deafness or 7. any other disability which may prevent the participant from participating or cooperating in the protocol. * Prisoners * Any contraindication for MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| University of California San Diego (UCSD) Performance-Based Skills Assessment (UPSA) | 30 minutes | Measure independent functioning in everyday life for controls and individuals with MCI |
| Medication Management Ability Assessment | 15 minutes | Measure independent management of medications in controls and individuals with MCI |
| Lawton iADL (instrumental activities of daily living) scale | 5 minutes | Measure ability to perform instrumental activities of daily living in controls and individuals with MCI |
Countries
United States
Outcome results
None listed