Smoking Cessation
Conditions
Brief summary
The purpose of this research study is to help determine whether practicing resisting the urge to smoke changes brain function or behavior among smokers.
Detailed description
The study is comprised of two parts: a pilot to test procedures to be used in the study, followed by the study. The pilot phase of this study will enroll 30 participants. The main study will enroll 80 after the pilot phase is completed. The pilot phase includes all of the same procedures as the main study.
Interventions
BEHAVIORALDelay time to first cigarette
Participants asked to delay time until they smoke first cigarette of the day.
BEHAVIORALTherapy
Participants receive tips on how to resist the urge to smoke and control cravings to smoke.
Sponsors
American Cancer Society, Inc.
University of Kansas Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Masking description
Primary investigator was blinded to intervention assignment
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Smoke \> 10 cigarettes per day for the last 6 months * Smokes first cigarette within 60 minutes after waking * Vision should be normal or corrected-to-normal (to ensure that they can accurately see the images on the screen and select the appropriate response) * Willing to complete all appointments and change smoking behaviors for 2 weeks * No quit attempts or attempts to cut back in the last 30 days * No plans to quit in the next 30 days * High school graduate or General Eduction Diploma (GED)
Exclusion criteria
* Serious medical illness unsuitable for the magnetic resonance imaging (MRI) scanner based on best clinical judgment * Any neurologic or psychiatric disorder except depression, anxiety (including post-traumatic stress disorder), or attention-deficit disorder/attention-deficit hyperactivity disorder * Currently taking anti-seizure medication * History of concussion * Body mass index (BMI) over 50 * Left-handedness * History of alcohol or other substance dependence or current abuse; * Risk for hazard due to magnetic fields such as metal in the body surgically or accidentally (e.g., pacemaker, cochlear implants, aneurysm clips, intravascular stents or coils, spinal shunt, injury involving bullets, shrapnel or metal implanted in their body, etc) * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Increase in percent blood oxygenation level dependent (BOLD) signal change in cognitive control network in response to smoking versus nonsmoking cues | Baseline (Day 7) to End of Study (Day 22) | Change measured via functional magnetic resonance imaging (fMRI) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Decrease in percent (BOLD) signal change in reward network in response to smoking versus nonsmoking cues | Baseline (Day 7) to End of Study (Day 22) | Change measured via functional magnetic resonance imaging (fMRI) |
Countries
United States
Outcome results
None listed