Bacterial Infections, Sonic Hedgehog Expression, Varicocele, VEGF Expression, Viral Infection
Conditions
Brief summary
This study is to answer the question is there any relationship between viral ( HSV 1 , HSV 2 , HPV 6/11, CMV, HHV 6 , HHV 8, BKV) or bacterial (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Fusobacterium nucleatum) infection and occurrence of varicocele in men.
Interventions
During the procedure approximately 1cm long fragment of varicose vein will be taken for further investigation.
PROCEDUREopen hernia repair
During the procedure approximately 1cm long fragment of spermatic cord vein will be taken for further investigation.
Sponsors
Medical University of Warsaw
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* in experimental arm - varicocele grade II or III and infertility and/or pain
Exclusion criteria
* in control arm: presence of varicocele in ultrasound before surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of presence od viral or bacterial infection, level of expression of SHH and VEGF in varicose vein wall. . | one year after finishing recruitment | Qualitative and quantitive analysis (presence and concentration - µl or U/µl in two different laboratory tests.) to detect genetic material (DNA, mRNA) of bacteria/viruses will be performed. The outcomes from both gropus will be compared. |
Countries
Poland
Outcome results
None listed