Infertility, Female
Conditions
Keywords
Poor responders
Brief summary
This study evaluates the efficacy of pre- IVF treatment with transdermal testosterone to enhance ovarian response in poor responders. a randomized controlled trial with two groups, treatment group with transdermal testosterone before IVF treatment and a control group with no treatment.
Detailed description
One of the major challenges of Assisted reproduction technology is treating women with low ovarian response,those women achieve very poor pregnancy rate with IVF. in recent years there is a focus
Interventions
DRUGTestosterone gel
treatment with testosterone gel
Sponsors
Wolfson Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 42 Years
Healthy volunteers
Yes
Inclusion criteria
* infertility patients undergoing ART regular menses normal function of thyroid, liver and kidney normal BMI (19.3-28.9) without use of any fertility drugs in the previous two months
Exclusion criteria
* patients with recurrent implantations failure (3 cycles and more) previous ovarian surgery uncontrolled medical illness severe endometriosis (stage 3-4) contraindication for testosterone use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of retrieved oocytes | 2 year | number of oocytes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| number of clinical pregnancies | 2.5 years | number of pregnancies with fetal cardiac activity |
Countries
Israel
Contacts
Primary Contactamir Mr shalev, MD
Backup Contactariel Mr weissman, Proffesor
Outcome results
None listed