Pulmonary Hypertension
Conditions
Brief summary
This study is being conducted to determine whether patients with advanced pulmonary hypertension when treated with cardiac resynchronization therapy improve hemodynamically and/or receive clinical benefit.
Detailed description
This study aims to determine whether stimulating earlier activation of the failing right ventricle in pulmonary hypertension reduces the effects of interventricular dependence in human subjects, thereby improving overall cardiac function and symptoms in patients with pulmonary hypertension and right ventricle failure with NYHA Class 3-4 symptoms.
Interventions
A CRT device sends small electrical impulses to both lower chambers of the heart to help them beat together in a more synchronized pattern.
Sponsors
Dr. Daniel P Morin, MD MPH FHRS
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Pulmonary hypertension, defined as pulmonary artery systolic pressure greater than 40 mm Hg by transthoracic echocardiogram or right heart catheterization * LVEF ≥ 50% * Baseline 6MWT distant \<400 meters * Baseline NYHA Functional class ≥ III
Exclusion criteria
* LVEF \< 50% * 6MWT duration \> 400 meters * NYHA Functional class \< III * Left bundle branch block * Non-sinus rhythm * Severe aortic stenosis (Aortic valve area \< 1 cm2) * Severe mitral regurgitation * Acute cardiac failure * Dependency on intravenous inotropies * Severe obstructive pulmonary disease * Hypertrophic obstructive cardiomyopathy * Amyloidosis * Dependence on pacing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 15% increase in cardiac output at the optimal VV interval over baseline cardiac output | the procedure | Primary Outcome |
Countries
United States
Outcome results
None listed