Cardiac Remodeling, Ventricular
Conditions
Keywords
echocardiography, intraventricular pressure gradients, cardiac remodeling, athletes
Brief summary
The uncertainty concerning the onset and the extent of cardiac remodeling in response to intensive training hinders medical evaluation by physician. A better knowledge of the physiology of cardiac adaptation to training will enable physicians to correctly determine whether observed patterns of cardiac remodeling are physiological or pathological. This prospective study proposes to assess in a trained-athlete population the cardiac remodeling in response to intensive exercise training. This study is observational, we do not interfere with athlete's training.
Interventions
OTHERelectrocardiogram and echocardiography
We retrieved all electrocardiograms and echocardiography made during the clinical examination of each athlete and each sedentary control. * Standard 12 lead ECG * Trans-thoracic echocardiography examination of cardiac function, morphology and intracardiac flow.
Sponsors
University Hospital, Caen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age \> 18yrs old * Ability to give written consent for participating in the study
Exclusion criteria
* Age \< 18yrs old * Cardiac diseases, arterial hypertension, cardiac devices, diabetes, renal, liver or pulmonary failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of ventricular response to exercise training by echocardiography. | Day 1 | 1. 2D- morphological and functional parameters of both left and right ventricles: * end-diastolic and end-systolic dimensions (cm) * left ventricular mass (g) * ventricular end-diastolic and end-systolic areas (cm²) * ventricular ejection fraction (%) * atrial volumes (ml) * diastolic indices by pulsed wave Doppler and tissue Doppler (cm/s) * myocardial deformation by speckle tracking (%) 2. 3D- morphological and functional parameters of both left and right ventricles: * ventricular full volumes (ml) * ejection fraction (%) 3. Intracardiac flow measurements by color Doppler M-mode: estimation of intra ventricular pressure gradients between the base and the apex (mmHg). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of ventricular response to exercise training by electrocardiogram | Day 1 | * heart rate (bpm), * ventricular hypertrophy (mV) * atrial remodeling (mV) |
| Sport and medical history questionnaire | Day 1 | exercise training program, medical past history, cardiovascular risk factors, treatments, doping. |
Countries
France
Outcome results
None listed