Anesthesia
Conditions
Keywords
Dexmedetomidine, brain arteriovenous malformation, embolization, post-operative hypertension
Brief summary
Aim of this trial is to study the effect of Dexmedetomidine on post-operative blood pressure in patients undergoing brain arteriovenous malformation embolization. The patients were randomized allocated to either Dexmedetomidine group or Control group. Patients in Dexmedetomidine group will receive intravenous Dexmedetomidine while the control group will receive normal saline. Post-operative anti-hypertensive drug, Visual analogue score,post-operative analgesics consumption, Quality of Recovery score, Ramsay score, and adverse events were recorded.
Detailed description
Aim of this trial is to study the effect of Dexmedetomidine on post-operative blood pressure in patients undergoing brain arteriovenous malformation embolization. The patients were randomized allocated to either Dexmedetomidine group or Control group according to a random number. Patients in Dexmedetomidine group will receive intravenous Dexmedetomidine while the control group will receive normal saline. Post-operative anti-hypertensive drug, Visual analogue score,post-operative analgesics consumption, Quality of Recovery score-15 items, Ramsay score, and adverse events were recorded.
Interventions
DRUGDexmedetomidine
1.2 μg/kg Dexmedetomidine was administered intravenously constantly after tracheal extubation.
OTHERnormal saline
equal volume of normal saline was administered intravenously constantly after tracheal extubation.
Sponsors
Nan Jiang
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Masking description
this investigation is a triple mask study. The patiens, the care providers and Outcome Assessor will not allowed to know the grouping information.
Intervention model description
two parallel groups
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing brain arteriovenous malformation embolization in the fist affiliated hospital, Sun Yat-sen University, aged 18-65 years, available to chat with,and the tracheal tube was extubated after surgery immediately.
Exclusion criteria
* abuse anesthetic analgesics and sedative drugs, or allergic to Dexmedetomidine or other anesthetics, hypotension or bradycardia before surgery, severe pulmonary disease with saturation of pulse oximetry less than 90% before surgery, or patients refused to attend in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| urapidil consumption | the end of the 6th hour after tracheal extubation | urapidil consumption was recorded by nurses every hour |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| urapidil consumption on POD2 | the total consumption of urapidil on post-operative day 2. | urapidil consumption was recorded by nurses every hour |
| Visual Analogue score | the end of the 6th hour after tracheal extubation | visual analogue score was measured by visual analogue scale |
| Visual Analogue score at 24th hour | the end of the 24th hour after tracheal extubation | visual analogue score was measured by visual analogue scale |
| Visual Analogue score at 48th hour | the end of the 48th hour after tracheal extubation | visual analogue score was measured by visual analogue scale |
| Quality of Recovery Score | the end of the 6th hour after tracheal extubation | Quality of Recovery Score was measured by a 15-item quality of recovery scale |
| Quality of Recovery Score at 24th hour | the end of the 24th hour after tracheal extubation | Quality of Recovery Score was measured by a 15-item quality of recovery scale |
| Quality of Recovery Score at 48th hour | the end of the 48th hour after tracheal extubation | Quality of Recovery Score was measured by a 15-item quality of recovery scale |
| Analgesics consumption | the end of the 6th hour after tracheal extubation | Analgesics consumption was recorded by nurse every hour |
| urapidil consumption on POD1 | the total consumption of urapidil on post-operative day 1. | urapidil consumption was recorded by nurses every hour |
| Analgesics consumption on POD2 | the total consumption of urapidil on post-operative day 2. | Analgesics consumption was recorded by nurse every hour |
| Bradycardia | the end of the 6th hour after tracheal extubation | a heart rate of lower than 50 beats per minute was identified as bradycardia, frequency of bradycardia was recorded by nurse |
| Bradycardia at 24th hour | the end of the 24th hour after tracheal extubation | a heart rate of lower than 50 beats per minute was identified as bradycardia, frequency of bradycardia was recorded by nurse |
| Bradycardia at 48th hour | the end of the 48th hour after tracheal extubation | a heart rate of lower than 50 beats per minute was identified as bradycardia, frequency of bradycardia was recorded by nurse |
| PONV | the end of the 6th hour after tracheal extubation | post-operative nausea and vomiting (PONV) was recorded by nurse |
| PONV at 24th hour | the end of the 24th hour after tracheal extubation | post-operative nausea and vomiting (PONV) was recorded by nurse |
| PONV at 48th hour | the end of the 48th hour after tracheal extubation | post-operative nausea and vomiting (PONV) was recorded by nurse |
| Analgesics consumption on POD1 | the total consumption of urapidil on post-operative day 1. | Analgesics consumption was recorded by nurse every hour |
Countries
China
Contacts
Primary ContactNan Jiang, PhD
Outcome results
None listed