Headache, Migraine
Conditions
Brief summary
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.
Detailed description
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide. With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.
Interventions
OTHERCarbon monoxide
carbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass
OTHERAIR
Room air will be administered as placebo
Sponsors
Danish Headache Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * Aged 18-50 * 50-100 kg
Exclusion criteria
* Tension type headache more than once/month * Other primary headaches * Daily medication except contraceptives * Drug taken within 4 times the halflife for the specific drug except contraceptives * Pregnant or lactating women * Exposure to radiation within the last year * Headache within the last 24 hours before start of trial * Hypertension * Hypotension * Respiratory or cardiac disease * Smoking * Primary relatives with current or previous migraine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Headache scores, 12 hours | 12 hours | Comparison between carbon monoxide and placebo (atmospheric air) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Facial blood flow | [ Time Frame: 0-180 min ] | Carbon monoxide induced changes in facial blood flow before and after inhalation. |
Countries
Denmark
Outcome results
None listed