Cardiovascular Imaging and Biomarker Analyses (CIBER)

Conditions

Coronary Artery Disease, Heart Diseases, Heart Failure

Brief summary

Cardiovascular Imaging and Biomarker Analyses (CIBER) is a single-center, prospective and observational study evaluating the expression of novel biomarkers in patients undergoing cardiacvascular imaging within clinical routine care. It is aimed to evaluate associations with biomarker expressions with ascertained cardiac imaging parameters.

Detailed description

Cardiovascular Imaging and Biomarker Analyses (CIBER) is a single-center, prospective and observational study evaluating the expression of novel biomarkers in patients undergoing cardiacvascular imaging within clinical routine care. It is aimed to evaluate associations with biomarker expressions with ascertained cardiac imaging parameters. Furthermore the prognostic value of biomarkers and imaging parameters on mid-term and long-term prognosis will be evaluated. Novel biomarkers will comprise blood derived biomarkers including neurohormones, proteins, cytokines, microRNAs and metabolomics.

Uzair Ansari, Michael Behnes, Júlia Hoffmann, Kathrin Weidner, Philip Kuche et al. (15 authors)

Scandinavian Cardiovascular Journal2021-11-054 citations

10.1080/14017431.2021.1995036

Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score.

Rusnak J, Behnes M, Henzler T, Reckord N, Vogler N, Meyer M, Hoffmann U, Natale M, Hoffmann J, Hamed S, Weidner K, Lang S, Mukherji A, Haubenreisser H, Schoenberg SO, Borggrefe M, Bertsch T, Akin I.

2017-11-168 citations

10.1186/s40001-017-0290-9

High Sensitivity Troponins Discriminate Different Morphologies of Coronary Artery Plaques Being Assessed by Coronary Computed Tomography Angiography

Jonas Rusnak, Michael Behnes, Nadine Reckord, Ursula Hoffmann, Michèle Natale et al. (15 authors)

Disease Markers2017-01-012 citations

10.1155/2017/9306409

Interventions

DIAGNOSTIC_TESTEchocardiography

Patients are undergoing echocardiography

DIAGNOSTIC_TESTmagnetic resonance imaging

Patients are undergoing magnetic resonance imaging

DIAGNOSTIC_TESTcomputed tomography

Patients are undergoing computed tomography

DIAGNOSTIC_TESTblood withdrawl

Peripheral blood samples are being collected from all patients

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* patients with low to intermediate risk for coronary artery disease

Exclusion criteria

* under 18 years * mechanical heart valve * pulmonary embolism * deep vein thrombosis * myocardial infarction within the last 3 months * electrical cardioversion within 30 days * status after heart transplant * transient ischemic attack (TIA) or stroke within last 30 days * intracerebral bleeding within the last 2 months * acute infection * existing or planned pregnancy * chronic kidney disease with eGFR \< 40 ml/min

Design outcomes

Primary

Measure	Time frame
Biomarker levels before cardiac imaging	24 hours before cardiac imaging

Countries

Germany

Outcome results

None listed