Postoperative Pain
Conditions
Keywords
Rectus sheath block, Postoperative pain,TNF alpha and IL-6
Brief summary
Good quality of postoperative analgesia would lead to attenuate or prevent the adverse effects on the common functions of the immune system. We compared the effect of epidural analgesia versus rectus sheath block on postoperative pain and proinflammatory cytokines following malignant urological surgery.
Detailed description
Study groups: 60 patients were included in the study randomly allocated into two groups of 30 patients. Rectus sheath group (RSB): Each patient received bilateral single shot ultrasound guided rectus sheath block under complete aseptic condition in a dose of 30 ml of bupivacaine 0.25% in each side immediately after induction of general anaesthesia. Control group: the patients did not receive any intervention after anaesthesia induction.
Interventions
DRUGBupivacaine 0.25%
Each patient received bilateral single shot ultrasound guided rectus sheath block under complete aseptic condition in a dose of 30 ml of bupivacaine 0.25% in each side immediately after induction of general anaesthesia
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Male patients their age over 40 years, classified ASA I, II or III, undergoing radical resection of cancer prostate, through midline abdominal incision under general anaesthesia.
Exclusion criteria
Contraindications to rectus sheath block as patient refusal, coagulopathy, local infection and allergy to bupivacaine. Planned transverse or oblique abdominal incision, extensive existing midline abdominal scarring or pre-existing chronic abdominal pain.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cumulative opioid consumption | 24 hours postoperative | study the effect of RSB on cumulative opioid consumption at 24 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Numerical rating scale (NRS) | 24 hours postoperative | evaluate postoperative pain intensity by NRS |
| time to first anlgesic request | 24 hours postoperative | the first time receiving IV-PCA bolus injection |
| serum levels of TNF-α | at 24 hours postoperative | Proinflamatory cytokines |
| Serum level of IL-6 | at 24 hours postoperative | Proinflamatory cytokines |
Countries
Egypt
Outcome results
None listed