Rudolph: Nasal Microbiota With Red and Sore Nose

RUDOLPH Study Nasal Microbiota and Concurrent Nose Soreness Associated With Common Cold Infection - a Pilot Using the HRV-16 Challenge Model in Healthy Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03073837

Enrollment

Registered

2017-03-08

Start date

2017-03-20

Completion date

2017-08-15

Last updated

2017-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dermatitis

Brief summary

This pilot study will utilize the experimental rhinovirus infection model to study changes in skin microbiota in relation to skin erythema and soreness.

Interventions

OTHERRhinovirus Challenge

Challenge with HRV-16 virus

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* self reported proneness to developing symptoms of nose redness and/or soreness * sero-negative to HRV-16 at screening

Exclusion criteria

* confirmed or self-reported allergic rhinitis * history of nasal or otologic surgery * use of anti-inflammatory medication, recent antibiotics or anti-histamines

Design outcomes

Primary

Measure	Time frame	Description
nasal microbiota composition and occurrence of nose redness and soreness during rhinovirus infection	change from baseline compared to day 22	Taxonomic classification of bacterial strains before and after HRV-16 virus for subjects with a VAS score rating \>37mm

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026