Follicular Fluid, Bioavailable Vitamin D and Embryo Quality Markers

Correlation Between Follicular Fluid Levels of Bioavailable Vitamin D and Embryo Quality Markers: Euploid Status, Morphokinetics and Mitochondrial DNA Content Among UAE Women Undergoing an IVF Cycle

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03073720

Enrollment

Registered

2017-03-08

Start date

2017-07-26

Completion date

2019-12-31

Last updated

2020-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin D Deficiency

Brief summary

To determine the correlation between bioavailable Vitamin D values and euploid status of the embryos in larger size follicles from UAE women undergoing in vitro fertilization procedures.

Detailed description

To study the possible correlation between bioavailable vitamin D values in follicular fluid and embryo quality markers. To correlate bioavailable Vitamin D values in follicular fluid from large size follicles with embryo euploid status as our main objective. Secondly, looking at morphokinetics and mitochondrial content of these embryos. Taking into account that most of UAE patients have deficiency or insufficiency of Vitamin D, if there is a correlation found we will understand better the underlying mechanism by which bioavailable Vitamin D levels may be affecting embryo quality, therefore IVF outcomes.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 48 Years

Healthy volunteers

Yes

Inclusion criteria

* Women´s Age \>18 - ≤43 years. * BMI 19-33 * Male partner will produce fresh sperm sample on the same day of the egg collection procedure. * Women with more than 10 follicles at the time of the trigger * At the time of egg retrieval, at least three follicles between 14-\<17 mm and three follicles ≥17 mm. * Women ≤35 years old stimulation with rFSH antagonist * Women ≥36 years old stimulation with highly-purified human menopausal gonadotropins (hpHMG) specifically for the additional LH. * Middle East population

Exclusion criteria

* Polycystic ovarian syndrome (according to the Rotterdam Criteria). * Patients at risk of OHSS, according to the criteria previously described by Papanikolau et al. (23). * History of endometriosis, classified according to the American Fertility Society (AFS) as stage 3 or more. * Severe male factor definition (\<2 million of sperm per ml of ejaculate) * Recurrent miscarriage (3 miscarriages) * Smokers * History of chemotherapy or radiotherapy

Design outcomes

Primary

Measure	Time frame	Description
Vitamin D values in follicular fluid and embryo quality markers among UAE women undergoing an IVF cycle	6-10 months	A correlation between vitamin D levels and embryo development patterns

Countries

United Arab Emirates

Outcome results