Blood Pressure, Cardiovascular Risk Factor
Conditions
Brief summary
The primary purpose of this study is to explore the effect of high versus normal egg-based protein meals on acute exercise-induced elevated blood pressure.
Detailed description
This study is designed to assess BP changes during and post- exercise after consumption of a test breakfast. The design consists of three visits. The first visit will assess each participants aerobic exercise capacity (VO2 max). Visit 2 and 3 will be clinical testing days where the subject will consume either the 13g or 30g protein breakfast in a randomized cross-over manner and perform the exercise intervention. BP changes will be monitored before and after breakfast consumption, during the exercise intervention,
Interventions
OTHERNormal Protein
Consumption of a normal protein (NP), egg-based (13 g protein; whole eggs) breakfast bowl
OTHERHIgh Protein
Consumption of a high protein (HP), egg-based (30 g protein; whole eggs) breakfast bowl
Sponsors
Purdue University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Care provider will randomize participants and keep the participant, investigator and outcomes assessor blinded to the randomization.
Intervention model description
subject will consume either the 13g or 30g protein breakfast in a randomized cross-over manner
Eligibility
Sex/Gender
ALL
Age
21 Years to 121 Years
Healthy volunteers
Yes
Inclusion criteria
* Pre-hypertensive (systolic, 120-139 mm Hg; diastolic, 80-89 mm Hg * Age ≥ 21 * Body weight \<300 lb (136 kg) * BMI between 20 and 34.9 kg/m2 * Fasting plasma glucose \<6.1 mmol/L, * total cholesterol \<6.7 mmol/L * LDL cholesterol \<4.1 mmol/L * TG \<4.5 mmol/L * No pre-existing or history of cardiovascular, renal or liver disease * Not currently or previously (past 6 mo) consuming a weight-loss diet or other special/non-balanced diets * No weight loss/gain (±4.5 kg) within the past 6 mo * No physical impairments preventing properly exercise execution * No caffeine intake the day of testing
Exclusion criteria
* Hypertensive * Body weight ≥ 300 lb * BMI \<20 or \>35 kg/m2 * Pregnant or planning pregnancy * Unwilling to consume study foods and beverages * Fasting plasma glucose ≥6.1 mmol/L * Total cholesterol ≥6.7 mmol/L * LDL cholesterol ≥4.1 mmol/L * TG ≥4.5 mmol/L * acute illness * smoking * diabetic * pre-existing or history of cardiovascular, renal or liver disease * currently or previously (past 6 mo) consuming a weight-loss diet or other special/non-balanced diets * weight loss/gain (±4.5 kg) within the past 6 months * physical impairments preventing properly exercise execution * caffeine the day of testing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Pressure Changes | 6hr testing | Changes from Baseline to Post Systolic Blood Pressure during 30 minute exercise session |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vasoactive Molecules | 6 hrs | Vasoactive Molecules analysis using plasma |
Countries
United States
Outcome results
None listed