Periodontal Attachment Loss, Periodontal Pocket
Conditions
Keywords
flavonoids, tea, dietary intake, nutritional supplements, periodontal disease, healing, sanative therapy
Brief summary
Periodontitis is a chronic inflammatory disease that, if untreated, will lead to tooth loss. To treat periodontal disease, sanative therapy is used as a first line cost-effective strategy to manage periodontal disease and thus prevent tooth loss. Diet is emerging as a modifiable factor that may help an individual to more fully respond to treatments such as sanative therapy. Dietary flavonoids, abundant in fruits and tea, may be particularly beneficial. Patients with moderate to severe chronic generalized periodontitis and undergoing sanative therapy will be recruited for the study. Mean clinical attachment loss as well as other clinical measures will be assessed at baseline and 8 to 12 weeks following sanative therapy to measure periodontal healing. At baseline and follow-up appointment, the following will be assessed to examine associations with clinical measures of periodontal healing: intakes of macronutrients and micronutrients, fruits, vegetables and tea as well as supplement use and salivary markers of inflammation.
Detailed description
Periodontitis is a chronic oral infection that results in the breakdown of connective tissue and alveolar bone that support the teeth. Bacteria and the body's own immune system mediate the severity of periodontitis, where teeth may become loose, fall out or have to be removed. Sanative therapy is a non-surgical process invovling mechanical debridement of bacterial biofilms on roots of teeth, below the gum line. A previous study found that a diet higher in fruits and vegetables, beta-carotene, vitamin C, alpha-tocopherol, and fish oils (specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) was positively associated with periodontal healing after sanative therapy. There is some evidence that higher intakes of flavonoids and thus flavonoid-containing foods may benefit periodontal health. These foods include a wide variety of fruits and tea. The relationship of flavonoid intake within the overall dietary pattern has not been assessed in relation to recovery from sanative therapy and associated markers of improved periodontal health. The overall objective is to determine if higher dietary flavonoid intakes are associated with improved clinical outcomes after sanative therapy compared to individuals with lower intakes. At baseline and the follow-up appointment, the following will be assessed: dietary intakes of macronutrients and micronutrients using the Block 2015 food frequency questionnaire; intakes of fruit, vegetables and fiber using the Block Dietary Fruit-Vegetable-Fiber Screener; nutritional supplement use and tea intake using in specially developed questionnaires and salivary markers of inflammation.
Interventions
None listed
Sponsors
Dr. Peter C. Fritz, Periodontal Wellness & Implant Surgery
Brock University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients undergoing sanative therapy for moderate to severe chronic generalized periodontitis. Chronic periodontitis is classified as generalized if \>30% of sites are involved. Severity of periodontitis is based on the amount of clinical attachment loss (CAL) with moderate and severe chronic generalized periodontitis defined as 3 to 4 mm CAL or \> 5 mm CAL, respectively.
Exclusion criteria
* under 19 years of age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical Attachment Loss (CAL) (also called Periodontal Attachment Loss) | At baseline and at follow-up (8 to 12 weeks after completion of sanative therapy) | Periodontal healing is evaluated based on changes in clinical attachment loss (mm) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Probing Depth | At baseline and at follow-up (8 to 12 weeks after completion of sanative therapy) | Periodontal healing is evaluated based on changes in probing depth (mm) |
| Bleeding on Probing | At baseline and at follow-up (8 to 12 weeks after completion of sanative therapy) | Inflammation is determined by percent of bleeding sites that are measured at 6 sites per tooth |
| Plaque Index | At baseline and at follow-up (8 to 12 weeks after completion of sanative therapy) | O'Leary Plaque Score Index is a score of the total amount of plaque present at 4 surfaces of a tooth |
Other
| Measure | Time frame | Description |
|---|---|---|
| Dietary Nutrient Intakes | Completed at baseline and follow-up (8 to 12 weeks after completion of sanative therapy) | Dietary intakes measured using the BLOCK food frequency questionnaire |
| Salivary Markers of Inflammation | Measured at baseline and follow-up (8 to 12 weeks after completion of sanative therapy) | Specific markers of inflammation measured in saliva |
| Tea Intakes | Completed at baseline and follow-up (8 to 12 weeks after completion of sanative therapy) | Quantity of tea and type of tea consumed will be determined using a questionnaire |
| Servings of fruits, vegetables and fibre | Completed at baseline and follow-up (8 to 12 weeks after completion of sanative therapy) | A questionnaire called the Block Fruit-Vegetable-Fiber Screener is used to provide a score that pertains to number of servings of fruits, vegetables and fiber consumed over past month |
| Dietary Supplement Intakes | Completed at baseline and follow-up (8 to 12 weeks after completion of sanative therapy) | Intakes of specific dietary supplements measured using a dietary supplement questionnaire |
Countries
Canada
Outcome results
None listed