Spine Metastasis
Conditions
Brief summary
Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy
Interventions
RADIATIONStereotactic body radiotherapy
Stereotactic body radiotherapy
Sponsors
National University of Singapore
National University Hospital, Singapore
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥21 years of age * Proven metastatic disease, excluding haematological and germ cell neoplasms * Life expectancy \>3 months, Eastern Cooperative Oncology group (ECOG) 0-2
Exclusion criteria
* The patient must not have an allergy to gadolinium contrast that will limit the ability to image the tumour by MRI safely even with the use of premedication * eGFR \< 30 mL/min or if patient is suffering from acute renal insufficiency * Prior radiotherapy to the specified region * Recent surgery to affected spinal levels, or patients requiring immediate surgical intervention * Spinal instability score (SINS) \>12 * Symptomatic cord compression (Bilksy grade 2 or 3), or worsening neurological deficits * Body weight of more than 120kg * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reduction in vasculature | 3 month | Reduction in vasculature measured by changes on Dynamic Contrast enhanced MRI |
Countries
Singapore
Contacts
Primary ContactBALAMURUGAN VELLAYAPPAN, MBBS, FRANZCR
Outcome results
None listed